Manipulation of anti-LDH-B response by T suppressor factors

Z. Ikezawa, Z. A. Nagy, J. Klein

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Hybridomas produced by fusion between the BW5147 thymoma and an LDH-B-specific B10.A(2R) suppressor T cell line secrete two T suppressor factors (TsF). One factor (TsF-A) shares Mhc determinants with the A(α)A(β) molecule and suppresses proliferating Th cells; the other (TsF-E) shares determinants with the E(α)E(β) molecule and it inhibits the maturation of the T suppressor (Ts) cells. Here we demonstrate that the two factors can be used to alter the immune response status of cultured T lymphocytes of an animal. When added to a culture of LDH-B-primed cells or injected into mice, the TsF-A turns responders into nonresponders, presumably by blocking the proliferation of the Th cells. The TsF-E converts nonresponder cultures or mice into responders, presumably by preventing the differentiation of Ts cells. As there are good prospects for obtaining TsF in large quantities and in a highly purified form, this manipulation of the immune response by the deployment of specific factors promises to become an efficient new method of immunotherapy.

Original languageEnglish (US)
Pages (from-to)1605-1607
Number of pages3
JournalJournal of Immunology
Volume132
Issue number4
StatePublished - Jan 1 1984

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Immunologic Suppressor Factors
T-Lymphocytes
Thymoma
Hybridomas
Immunotherapy
lactate dehydrogenase 1
Cell Proliferation
Cell Line

All Science Journal Classification (ASJC) codes

  • Immunology

Cite this

Ikezawa, Z., Nagy, Z. A., & Klein, J. (1984). Manipulation of anti-LDH-B response by T suppressor factors. Journal of Immunology, 132(4), 1605-1607.
Ikezawa, Z. ; Nagy, Z. A. ; Klein, J. / Manipulation of anti-LDH-B response by T suppressor factors. In: Journal of Immunology. 1984 ; Vol. 132, No. 4. pp. 1605-1607.
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Ikezawa, Z, Nagy, ZA & Klein, J 1984, 'Manipulation of anti-LDH-B response by T suppressor factors', Journal of Immunology, vol. 132, no. 4, pp. 1605-1607.

Manipulation of anti-LDH-B response by T suppressor factors. / Ikezawa, Z.; Nagy, Z. A.; Klein, J.

In: Journal of Immunology, Vol. 132, No. 4, 01.01.1984, p. 1605-1607.

Research output: Contribution to journalArticle

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Ikezawa Z, Nagy ZA, Klein J. Manipulation of anti-LDH-B response by T suppressor factors. Journal of Immunology. 1984 Jan 1;132(4):1605-1607.