Mapping genes for drug chronotherapy

Kun Wei, Qian Wang, Jingwen Gan, Shilong Zhang, Meixia Ye, Claudia Gragnoli, Rongling Wu

Research output: Contribution to journalReview article

3 Citations (Scopus)

Abstract

Genome-wide association studies have been increasingly used to map and characterize genes that contribute to interindividual variation in drug response. Some studies have integrated the pharmacokinetic (PK) and pharmacodynamic (PD) processes of drug reactions into association mapping, gleaning new insight into how genes determine the dynamic relationship of drug effect and drug dose. Here, we present an evolutionary framework by which two distinct concepts, chronopharmacodynamics and heterochrony (describing variation in the timing and rate of developmental events), are married to comprehend the pharmacogenetic architecture of drug response. The resulting new concept, heterochronopharmacodynamics (HCPD), can better interpret how genes influence drug efficacy and drug toxicity according to the circadian rhythm of the body and changes in drug concentration.

Original languageEnglish (US)
Pages (from-to)1883-1888
Number of pages6
JournalDrug Discovery Today
Volume23
Issue number11
DOIs
StatePublished - Nov 1 2018

Fingerprint

Drug Chronotherapy
Chromosome Mapping
Pharmaceutical Preparations
Genes
Genome-Wide Association Study
Pharmacogenetics
Circadian Rhythm
Drug-Related Side Effects and Adverse Reactions
Pharmacokinetics

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Drug Discovery

Cite this

Wei, K., Wang, Q., Gan, J., Zhang, S., Ye, M., Gragnoli, C., & Wu, R. (2018). Mapping genes for drug chronotherapy. Drug Discovery Today, 23(11), 1883-1888. https://doi.org/10.1016/j.drudis.2018.06.011
Wei, Kun ; Wang, Qian ; Gan, Jingwen ; Zhang, Shilong ; Ye, Meixia ; Gragnoli, Claudia ; Wu, Rongling. / Mapping genes for drug chronotherapy. In: Drug Discovery Today. 2018 ; Vol. 23, No. 11. pp. 1883-1888.
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Wei, K, Wang, Q, Gan, J, Zhang, S, Ye, M, Gragnoli, C & Wu, R 2018, 'Mapping genes for drug chronotherapy', Drug Discovery Today, vol. 23, no. 11, pp. 1883-1888. https://doi.org/10.1016/j.drudis.2018.06.011

Mapping genes for drug chronotherapy. / Wei, Kun; Wang, Qian; Gan, Jingwen; Zhang, Shilong; Ye, Meixia; Gragnoli, Claudia; Wu, Rongling.

In: Drug Discovery Today, Vol. 23, No. 11, 01.11.2018, p. 1883-1888.

Research output: Contribution to journalReview article

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T1 - Mapping genes for drug chronotherapy

AU - Wei, Kun

AU - Wang, Qian

AU - Gan, Jingwen

AU - Zhang, Shilong

AU - Ye, Meixia

AU - Gragnoli, Claudia

AU - Wu, Rongling

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AB - Genome-wide association studies have been increasingly used to map and characterize genes that contribute to interindividual variation in drug response. Some studies have integrated the pharmacokinetic (PK) and pharmacodynamic (PD) processes of drug reactions into association mapping, gleaning new insight into how genes determine the dynamic relationship of drug effect and drug dose. Here, we present an evolutionary framework by which two distinct concepts, chronopharmacodynamics and heterochrony (describing variation in the timing and rate of developmental events), are married to comprehend the pharmacogenetic architecture of drug response. The resulting new concept, heterochronopharmacodynamics (HCPD), can better interpret how genes influence drug efficacy and drug toxicity according to the circadian rhythm of the body and changes in drug concentration.

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Wei K, Wang Q, Gan J, Zhang S, Ye M, Gragnoli C et al. Mapping genes for drug chronotherapy. Drug Discovery Today. 2018 Nov 1;23(11):1883-1888. https://doi.org/10.1016/j.drudis.2018.06.011