Mapping of class alpha glutathione S-transferase 2 (Gst-2) genes to the vicinity of the d locus on mouse chromosome 9

Masanori Kasahara, Eriko Matsumura, Graham Webb, Philip G. Board, Felipe Figueroa, Jan Klein

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

Recombinant inbred strains of mice were used to localize the genes coding for the class alpha glutathione S-transferase 2 (Gst-2). The genes showed three distinct strain distribution patterns, indicating that they occur in at least three clusters separable by recombination. All three clusters are located in the vicinity of the d locus on mouse chromosome 9, but two of them are closer to d than the third. Linked to Gst-2 on mouse chromosome 9 are two enzyme-encoding loci, Pgm-3 and Mod-1. The human counterparts of Gst-2, Pgm-3, and Mod-1 map to 6p12, 6q12, and 6q12, respectively. Thus, the pericentric region of human chromosome 6 has its homolog in the segment spanning Gst-2, Pgm-3, and Mod-1 on mouse chromosome 9. The fact that the syntenic group extends across the centromere of human chromosome 6 can best be explained by a pericentric inversion postulated to have taken place in the primate lineage leading to Catarrhini.

Original languageEnglish (US)
Pages (from-to)90-96
Number of pages7
JournalGenomics
Volume8
Issue number1
DOIs
StatePublished - Sep 1990

All Science Journal Classification (ASJC) codes

  • Genetics

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