Marginal maternal zinc deficiency in lactating mice reduces secretory capacity and alters milk composition

Colleen Dempsey, Nicholas H. McCormick, Thomas P. Croxford, Young Ah Seo, Arthur Grider, Shannon L. Kelleher

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Dietary analysis predicts that marginal Zn deficiency is common in women of reproductive age. The lack of reliable biomarkers limits the capacity to assess Zn status and consequently understand effects of maternal Zn deficiency. We determined effects of marginal maternal Zn deficiency on mammary gland function, milk secretion, and milk composition in mice. Mice (n = 12/diet) were fed marginal (ZD; 15 mg Zn/kg diet) or adequate (ZA; 30 mg Zn/kg diet) Zn diets for 30 d prior to conception through mid-lactation. Mice fed the ZD had a higher plasma Zn concentration (~20%; P < 0.05) but lower milk Zn concentration (~15%; P , 0.05) compared with mice fed the ZA. ZnT2 abundance was higher (P < 0.05) in mice fed the ZD compared with mice fed the ZA; no effect on ZnT4 abundance was detected. The Zn concentration of mammary gland mitochondria tended to be ~40% greater in mice fed ZD (P = 0.07); this was associated with apoptosis and lower milk secretion (~80%; P<0.01). Total milk protein was ~25% higher (P<0.05), although the abundance of the major milk proteins (caseins and whey acidic protein) was lower (P < 0.05) in mice fed the ZD. Proteomic analysis of milk proteins revealed an increase (P,0.05) in four proteins in mice fed the ZD. These findings illustrate that marginal maternal Zn deficiency compromises mammary gland function and milk secretion and alters milk composition. This suggests that lactating women who consume inadequate Zn may not produce and/or secrete an adequate amount of high quality milk to provide optimal nutrition to their developing infant.

Original languageEnglish (US)
Pages (from-to)655-660
Number of pages6
JournalJournal of Nutrition
Volume142
Issue number4
DOIs
StatePublished - Apr 1 2012

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Zinc
Milk
Mothers
Milk Proteins
Human Mammary Glands
Diet
Human Milk
Caseins
Lactation
Proteomics
Mitochondria
Biomarkers
Apoptosis
Proteins

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Dempsey, C., McCormick, N. H., Croxford, T. P., Seo, Y. A., Grider, A., & Kelleher, S. L. (2012). Marginal maternal zinc deficiency in lactating mice reduces secretory capacity and alters milk composition. Journal of Nutrition, 142(4), 655-660. https://doi.org/10.3945/jn.111.150623
Dempsey, Colleen ; McCormick, Nicholas H. ; Croxford, Thomas P. ; Seo, Young Ah ; Grider, Arthur ; Kelleher, Shannon L. / Marginal maternal zinc deficiency in lactating mice reduces secretory capacity and alters milk composition. In: Journal of Nutrition. 2012 ; Vol. 142, No. 4. pp. 655-660.
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Dempsey, C, McCormick, NH, Croxford, TP, Seo, YA, Grider, A & Kelleher, SL 2012, 'Marginal maternal zinc deficiency in lactating mice reduces secretory capacity and alters milk composition', Journal of Nutrition, vol. 142, no. 4, pp. 655-660. https://doi.org/10.3945/jn.111.150623

Marginal maternal zinc deficiency in lactating mice reduces secretory capacity and alters milk composition. / Dempsey, Colleen; McCormick, Nicholas H.; Croxford, Thomas P.; Seo, Young Ah; Grider, Arthur; Kelleher, Shannon L.

In: Journal of Nutrition, Vol. 142, No. 4, 01.04.2012, p. 655-660.

Research output: Contribution to journalArticle

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