Marijuana smoking and the risk of head and neck cancer

Pooled analysis in the INHANCE Consortium

Julien Berthiller, Yuan Chin Amy Lee, Paolo Boffetta, Qingyi Wei, Erich M. Sturgis, Sander Greenland, Hal Morgenstern, Zuo Feng Zhang, Philip Lazarus, Joshua Muscat, Chu Chen, Stephen M. Schwartz, José Eluf Neto, Victor Wünsch Filho, Sergio Koifman, Maria Paula Curado, Elena Matos, Leticia Fernandez, Ana Menezes, Alexander W. Daudt & 3 others Gilles Ferro, Paul Brennan, Mia Hashibe

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Background: Marijuana contains carcinogens similar to tobacco smoke and has been suggested by relatively small studies to increase the risk of head and neck cancer (HNC). Because tobacco is a major risk factor for HNC, large studies with substantial numbers of never tobacco users could help to clarify whether marijuana smoking is independently associated with HNC risk. Methods: We pooled self-reported interview data on marijuana smoking and known HNC risk factors on 4,029 HNC cases and 5,015 controls from five case-control studies within the INHANCE Consortium. Subanalyses were conducted among never tobacco users (493 cases and 1,813 controls) and among individuals who did not consume alcohol or smoke tobacco (237 cases and 887 controls). Results: The risk of HNC was not elevated by ever marijuana smoking [odds ratio (OR), 0.88; 95% confidence intervals(95% CI), 0.67-1.16], and there was no increasing risk associated with increasing frequency, duration, or cumulative consumption of marijuana smoking. An increased risk of HNC associated with marijuana use was not detected among never tobacco users (OR, 0.93; 95% CI, 0.63-1.37; three studies) nor among individuals who did not drink alcohol and smoke tobacco (OR, 1.06; 95% CI, 0.47-2.38; two studies). Conclusion: Our results are consistent with the notion that infrequent marijuana smoking does not confer a risk of these malignancies. Nonetheless, because the prevalence of frequent marijuana smoking was low in most of the contributing studies, we could not rule out a moderately increased risk, particularly among subgroups without exposure to tobacco and alcohol.

Original languageEnglish (US)
Pages (from-to)1544-1551
Number of pages8
JournalCancer Epidemiology Biomarkers and Prevention
Volume18
Issue number5
DOIs
StatePublished - May 1 2009

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Marijuana Smoking
Head and Neck Neoplasms
Tobacco
Smoke
Odds Ratio
Alcohols
Confidence Intervals
Cannabis
Carcinogens
Case-Control Studies
Interviews

All Science Journal Classification (ASJC) codes

  • Epidemiology
  • Oncology

Cite this

Berthiller, J., Lee, Y. C. A., Boffetta, P., Wei, Q., Sturgis, E. M., Greenland, S., ... Hashibe, M. (2009). Marijuana smoking and the risk of head and neck cancer: Pooled analysis in the INHANCE Consortium. Cancer Epidemiology Biomarkers and Prevention, 18(5), 1544-1551. https://doi.org/10.1158/1055-9965.EPI-08-0845
Berthiller, Julien ; Lee, Yuan Chin Amy ; Boffetta, Paolo ; Wei, Qingyi ; Sturgis, Erich M. ; Greenland, Sander ; Morgenstern, Hal ; Zhang, Zuo Feng ; Lazarus, Philip ; Muscat, Joshua ; Chen, Chu ; Schwartz, Stephen M. ; Neto, José Eluf ; Wünsch Filho, Victor ; Koifman, Sergio ; Curado, Maria Paula ; Matos, Elena ; Fernandez, Leticia ; Menezes, Ana ; Daudt, Alexander W. ; Ferro, Gilles ; Brennan, Paul ; Hashibe, Mia. / Marijuana smoking and the risk of head and neck cancer : Pooled analysis in the INHANCE Consortium. In: Cancer Epidemiology Biomarkers and Prevention. 2009 ; Vol. 18, No. 5. pp. 1544-1551.
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abstract = "Background: Marijuana contains carcinogens similar to tobacco smoke and has been suggested by relatively small studies to increase the risk of head and neck cancer (HNC). Because tobacco is a major risk factor for HNC, large studies with substantial numbers of never tobacco users could help to clarify whether marijuana smoking is independently associated with HNC risk. Methods: We pooled self-reported interview data on marijuana smoking and known HNC risk factors on 4,029 HNC cases and 5,015 controls from five case-control studies within the INHANCE Consortium. Subanalyses were conducted among never tobacco users (493 cases and 1,813 controls) and among individuals who did not consume alcohol or smoke tobacco (237 cases and 887 controls). Results: The risk of HNC was not elevated by ever marijuana smoking [odds ratio (OR), 0.88; 95{\%} confidence intervals(95{\%} CI), 0.67-1.16], and there was no increasing risk associated with increasing frequency, duration, or cumulative consumption of marijuana smoking. An increased risk of HNC associated with marijuana use was not detected among never tobacco users (OR, 0.93; 95{\%} CI, 0.63-1.37; three studies) nor among individuals who did not drink alcohol and smoke tobacco (OR, 1.06; 95{\%} CI, 0.47-2.38; two studies). Conclusion: Our results are consistent with the notion that infrequent marijuana smoking does not confer a risk of these malignancies. Nonetheless, because the prevalence of frequent marijuana smoking was low in most of the contributing studies, we could not rule out a moderately increased risk, particularly among subgroups without exposure to tobacco and alcohol.",
author = "Julien Berthiller and Lee, {Yuan Chin Amy} and Paolo Boffetta and Qingyi Wei and Sturgis, {Erich M.} and Sander Greenland and Hal Morgenstern and Zhang, {Zuo Feng} and Philip Lazarus and Joshua Muscat and Chu Chen and Schwartz, {Stephen M.} and Neto, {Jos{\'e} Eluf} and {W{\"u}nsch Filho}, Victor and Sergio Koifman and Curado, {Maria Paula} and Elena Matos and Leticia Fernandez and Ana Menezes and Daudt, {Alexander W.} and Gilles Ferro and Paul Brennan and Mia Hashibe",
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Berthiller, J, Lee, YCA, Boffetta, P, Wei, Q, Sturgis, EM, Greenland, S, Morgenstern, H, Zhang, ZF, Lazarus, P, Muscat, J, Chen, C, Schwartz, SM, Neto, JE, Wünsch Filho, V, Koifman, S, Curado, MP, Matos, E, Fernandez, L, Menezes, A, Daudt, AW, Ferro, G, Brennan, P & Hashibe, M 2009, 'Marijuana smoking and the risk of head and neck cancer: Pooled analysis in the INHANCE Consortium', Cancer Epidemiology Biomarkers and Prevention, vol. 18, no. 5, pp. 1544-1551. https://doi.org/10.1158/1055-9965.EPI-08-0845

Marijuana smoking and the risk of head and neck cancer : Pooled analysis in the INHANCE Consortium. / Berthiller, Julien; Lee, Yuan Chin Amy; Boffetta, Paolo; Wei, Qingyi; Sturgis, Erich M.; Greenland, Sander; Morgenstern, Hal; Zhang, Zuo Feng; Lazarus, Philip; Muscat, Joshua; Chen, Chu; Schwartz, Stephen M.; Neto, José Eluf; Wünsch Filho, Victor; Koifman, Sergio; Curado, Maria Paula; Matos, Elena; Fernandez, Leticia; Menezes, Ana; Daudt, Alexander W.; Ferro, Gilles; Brennan, Paul; Hashibe, Mia.

In: Cancer Epidemiology Biomarkers and Prevention, Vol. 18, No. 5, 01.05.2009, p. 1544-1551.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Marijuana smoking and the risk of head and neck cancer

T2 - Pooled analysis in the INHANCE Consortium

AU - Berthiller, Julien

AU - Lee, Yuan Chin Amy

AU - Boffetta, Paolo

AU - Wei, Qingyi

AU - Sturgis, Erich M.

AU - Greenland, Sander

AU - Morgenstern, Hal

AU - Zhang, Zuo Feng

AU - Lazarus, Philip

AU - Muscat, Joshua

AU - Chen, Chu

AU - Schwartz, Stephen M.

AU - Neto, José Eluf

AU - Wünsch Filho, Victor

AU - Koifman, Sergio

AU - Curado, Maria Paula

AU - Matos, Elena

AU - Fernandez, Leticia

AU - Menezes, Ana

AU - Daudt, Alexander W.

AU - Ferro, Gilles

AU - Brennan, Paul

AU - Hashibe, Mia

PY - 2009/5/1

Y1 - 2009/5/1

N2 - Background: Marijuana contains carcinogens similar to tobacco smoke and has been suggested by relatively small studies to increase the risk of head and neck cancer (HNC). Because tobacco is a major risk factor for HNC, large studies with substantial numbers of never tobacco users could help to clarify whether marijuana smoking is independently associated with HNC risk. Methods: We pooled self-reported interview data on marijuana smoking and known HNC risk factors on 4,029 HNC cases and 5,015 controls from five case-control studies within the INHANCE Consortium. Subanalyses were conducted among never tobacco users (493 cases and 1,813 controls) and among individuals who did not consume alcohol or smoke tobacco (237 cases and 887 controls). Results: The risk of HNC was not elevated by ever marijuana smoking [odds ratio (OR), 0.88; 95% confidence intervals(95% CI), 0.67-1.16], and there was no increasing risk associated with increasing frequency, duration, or cumulative consumption of marijuana smoking. An increased risk of HNC associated with marijuana use was not detected among never tobacco users (OR, 0.93; 95% CI, 0.63-1.37; three studies) nor among individuals who did not drink alcohol and smoke tobacco (OR, 1.06; 95% CI, 0.47-2.38; two studies). Conclusion: Our results are consistent with the notion that infrequent marijuana smoking does not confer a risk of these malignancies. Nonetheless, because the prevalence of frequent marijuana smoking was low in most of the contributing studies, we could not rule out a moderately increased risk, particularly among subgroups without exposure to tobacco and alcohol.

AB - Background: Marijuana contains carcinogens similar to tobacco smoke and has been suggested by relatively small studies to increase the risk of head and neck cancer (HNC). Because tobacco is a major risk factor for HNC, large studies with substantial numbers of never tobacco users could help to clarify whether marijuana smoking is independently associated with HNC risk. Methods: We pooled self-reported interview data on marijuana smoking and known HNC risk factors on 4,029 HNC cases and 5,015 controls from five case-control studies within the INHANCE Consortium. Subanalyses were conducted among never tobacco users (493 cases and 1,813 controls) and among individuals who did not consume alcohol or smoke tobacco (237 cases and 887 controls). Results: The risk of HNC was not elevated by ever marijuana smoking [odds ratio (OR), 0.88; 95% confidence intervals(95% CI), 0.67-1.16], and there was no increasing risk associated with increasing frequency, duration, or cumulative consumption of marijuana smoking. An increased risk of HNC associated with marijuana use was not detected among never tobacco users (OR, 0.93; 95% CI, 0.63-1.37; three studies) nor among individuals who did not drink alcohol and smoke tobacco (OR, 1.06; 95% CI, 0.47-2.38; two studies). Conclusion: Our results are consistent with the notion that infrequent marijuana smoking does not confer a risk of these malignancies. Nonetheless, because the prevalence of frequent marijuana smoking was low in most of the contributing studies, we could not rule out a moderately increased risk, particularly among subgroups without exposure to tobacco and alcohol.

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DO - 10.1158/1055-9965.EPI-08-0845

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SP - 1544

EP - 1551

JO - Cancer Epidemiology Biomarkers and Prevention

JF - Cancer Epidemiology Biomarkers and Prevention

SN - 1055-9965

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