Mast cell transcriptional networks

Clifford M. Takemoto, Youl Nam Lee, Anil G. Jegga, Daniella Zablocki, Stephanie Brandal, Amir Shahlaee, Suming Huang, Ying Ye, Sivakumar Gowrisankar, Jimmy Huynh, Michael A. McDevitt

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Unregulated activation of mast cells can contribute to the pathogenesis of inflammatory and allergic diseases, including asthma, rheumatoid arthritis, inflammatory bowel disease, and multiple sclerosis. Absence of mast cells in animal models can lead to impairment in the innate immune response to parasites and bacterial infections. Aberrant clonal accumulation and proliferation of mast cells can result in a variety of diseases ranging from benign cutaneous mastocytosis to systemic mastocytosis or mast cell leukemia. Understanding mast cell differentiation provides important insights into mechanisms of lineage selection during hematopoiesis and can provide targets for new drug development to treat mast cell disorders. In this review, we discuss controversies related to development, sites of origin, and the transcriptional program of mast cells.

Original languageEnglish (US)
Pages (from-to)82-90
Number of pages9
JournalBlood Cells, Molecules, and Diseases
Volume41
Issue number1
DOIs
StatePublished - Jul 1 2008

Fingerprint

Gene Regulatory Networks
Mast Cells
Mast-Cell Leukemia
Cutaneous Mastocytosis
Systemic Mastocytosis
Parasitic Diseases
Hematopoiesis
Inflammatory Bowel Diseases
Bacterial Infections
Innate Immunity
Multiple Sclerosis
Cell Differentiation
Rheumatoid Arthritis
Asthma
Animal Models
Pharmaceutical Preparations

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Molecular Biology
  • Hematology
  • Cell Biology

Cite this

Takemoto, C. M., Lee, Y. N., Jegga, A. G., Zablocki, D., Brandal, S., Shahlaee, A., ... McDevitt, M. A. (2008). Mast cell transcriptional networks. Blood Cells, Molecules, and Diseases, 41(1), 82-90. https://doi.org/10.1016/j.bcmd.2008.02.005
Takemoto, Clifford M. ; Lee, Youl Nam ; Jegga, Anil G. ; Zablocki, Daniella ; Brandal, Stephanie ; Shahlaee, Amir ; Huang, Suming ; Ye, Ying ; Gowrisankar, Sivakumar ; Huynh, Jimmy ; McDevitt, Michael A. / Mast cell transcriptional networks. In: Blood Cells, Molecules, and Diseases. 2008 ; Vol. 41, No. 1. pp. 82-90.
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Takemoto, CM, Lee, YN, Jegga, AG, Zablocki, D, Brandal, S, Shahlaee, A, Huang, S, Ye, Y, Gowrisankar, S, Huynh, J & McDevitt, MA 2008, 'Mast cell transcriptional networks', Blood Cells, Molecules, and Diseases, vol. 41, no. 1, pp. 82-90. https://doi.org/10.1016/j.bcmd.2008.02.005

Mast cell transcriptional networks. / Takemoto, Clifford M.; Lee, Youl Nam; Jegga, Anil G.; Zablocki, Daniella; Brandal, Stephanie; Shahlaee, Amir; Huang, Suming; Ye, Ying; Gowrisankar, Sivakumar; Huynh, Jimmy; McDevitt, Michael A.

In: Blood Cells, Molecules, and Diseases, Vol. 41, No. 1, 01.07.2008, p. 82-90.

Research output: Contribution to journalArticle

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Takemoto CM, Lee YN, Jegga AG, Zablocki D, Brandal S, Shahlaee A et al. Mast cell transcriptional networks. Blood Cells, Molecules, and Diseases. 2008 Jul 1;41(1):82-90. https://doi.org/10.1016/j.bcmd.2008.02.005