Mast cell transcriptional networks

Clifford M. Takemoto, Youl Nam Lee, Anil G. Jegga, Daniella Zablocki, Stephanie Brandal, Amir Shahlaee, Suming Huang, Ying Ye, Sivakumar Gowrisankar, Jimmy Huynh, Michael A. McDevitt

Research output: Contribution to journalArticlepeer-review

25 Scopus citations

Abstract

Unregulated activation of mast cells can contribute to the pathogenesis of inflammatory and allergic diseases, including asthma, rheumatoid arthritis, inflammatory bowel disease, and multiple sclerosis. Absence of mast cells in animal models can lead to impairment in the innate immune response to parasites and bacterial infections. Aberrant clonal accumulation and proliferation of mast cells can result in a variety of diseases ranging from benign cutaneous mastocytosis to systemic mastocytosis or mast cell leukemia. Understanding mast cell differentiation provides important insights into mechanisms of lineage selection during hematopoiesis and can provide targets for new drug development to treat mast cell disorders. In this review, we discuss controversies related to development, sites of origin, and the transcriptional program of mast cells.

Original languageEnglish (US)
Pages (from-to)82-90
Number of pages9
JournalBlood Cells, Molecules, and Diseases
Volume41
Issue number1
DOIs
StatePublished - Jul 2008

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Molecular Biology
  • Hematology
  • Cell Biology

Fingerprint Dive into the research topics of 'Mast cell transcriptional networks'. Together they form a unique fingerprint.

Cite this