Maternal and fetal brain and plasma levels of cocaine and benzoylecgonine after acute or chronic maternal intravenous administration of cocaine

S. E. Robinson, E. K. Enters, G. F. Jackson, Vernon Chinchilli, J. R. Maher, K. P. McDowell, H. M. Allen, H. Guo

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Abstract

The effect of repeated i.v. administration of cocaine HCl (1.5, 3 or 6 mg/kg daily) from gestational day 8 through gestational day 18 was studied on maternal and litter parameters in the pregnant female Sprague-Dawley rat. These doses of cocaine had no significant effect on maternal weight gain or nutritional intake and did not significantly affect litter size. Levels of cocaine and its metabolite benzoylecgonine in the brain and plasma of the dams and their fetuses were measured on gestational day 18 at 1, 5, 20 or 60 min after a single injection or 11 daily i.v. injections of cocaine (6 mg/kg). The shape of the time courses for cocaine differed somewhat between dams and fetuses, with fetal plasma concentrations of cocaine initially being lower than those of their dams and then by 5 min becoming equivalent to those of their dams. Although plasma concentrations of cocaine soon equilibrated between dams and fetuses, plasma concentrations of benzoylecgonine did not. Interestingly, brain concentrations of cocaine did not differ between dams and fetuses. The most remarkable finding was that the relative distribution of cocaine between brain and plasma differed after chronic vs. acute treatment, with a relative shift in the distribution of cocaine from plasma to the brain in the fetuses, and, with the exception of the earliest time point measured, in the dams after repeated dosing.

Original languageEnglish (US)
Pages (from-to)1234-1239
Number of pages6
JournalJournal of Pharmacology and Experimental Therapeutics
Volume271
Issue number3
StatePublished - Jan 1 1994

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Cocaine
Intravenous Administration
Mothers
Brain
Fetus
benzoylecgonine
Litter Size
Injections
Weight Gain
Sprague Dawley Rats

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Pharmacology

Cite this

Robinson, S. E. ; Enters, E. K. ; Jackson, G. F. ; Chinchilli, Vernon ; Maher, J. R. ; McDowell, K. P. ; Allen, H. M. ; Guo, H. / Maternal and fetal brain and plasma levels of cocaine and benzoylecgonine after acute or chronic maternal intravenous administration of cocaine. In: Journal of Pharmacology and Experimental Therapeutics. 1994 ; Vol. 271, No. 3. pp. 1234-1239.
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Maternal and fetal brain and plasma levels of cocaine and benzoylecgonine after acute or chronic maternal intravenous administration of cocaine. / Robinson, S. E.; Enters, E. K.; Jackson, G. F.; Chinchilli, Vernon; Maher, J. R.; McDowell, K. P.; Allen, H. M.; Guo, H.

In: Journal of Pharmacology and Experimental Therapeutics, Vol. 271, No. 3, 01.01.1994, p. 1234-1239.

Research output: Contribution to journalArticle

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AU - Robinson, S. E.

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