Maternal exposure to air pollutant PM2.5 and PM10 during pregnancy and risk of congenital heart defects

Bin Zhang, Shengwen Liang, Jinzhu Zhao, Zhengmin Qian, Bryan A. Bassig, Rong Yang, Yiming Zhang, Ke Hu, Shunqing Xu, Tongzhang Zheng, Shaoping Yang

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Maternal exposure to ambient air pollution has increasingly been linked to congenital heart defects (CHDs). The objective of this study was to evaluate whether high levels of maternal exposure to PM2.5 and PM10 are related to increased risk of CHDs in Wuhan, China. We conducted a cohort study with a total of 105,988 live-born infants, stillbirths, and fetal deaths. The study included mothers living in the urban district of Wuhan during pregnancy over the 2-year period from 10 June 2011 to 9 June 2013. For each study participant, we assigned 1-month and 1-week averages of PM10 and PM2.5 exposure based on measurements obtained from the nearest exposure monitor to the living residence of mothers during their early pregnancy period. Logistic regression analyses were conducted to calculate the adjusted odds ratios (aORs) and 95% confidence intervals (CI) for the association between exposure to these ambient air pollutants during early pregnancy and CHDs. We observed an increased risk of CHDs, particularly ventricular septal defect (VSD), with increasing PM2.5 exposure. Using 1-week averages, we also observed significant monotonically increasing associations between PM2.5 exposure during weeks 7-10 of pregnancy and risk of VSD, with aORs ranging from 1.11 to 1.17 (95% CI: 1.02-1.20, 1.03-1.22, 1.05-1.24, and 1.08-1.26 separately) per a 10 μg/m3 change in PM2.5 concentration. Our study contributes to the small body of knowledge regarding the association between in utero exposure to air pollution and CHDs, but confirmation of these associations will be needed in future studies.

Original languageEnglish (US)
Pages (from-to)422-427
Number of pages6
JournalJournal of Exposure Science and Environmental Epidemiology
Volume26
Issue number4
DOIs
StatePublished - Jun 1 2016

Fingerprint

Maternal Exposure
Air Pollutants
Congenital Heart Defects
Pregnancy
Defects
Air
Ventricular Heart Septal Defects
Air Pollution
Odds Ratio
Air pollution
Confidence Intervals
Fetal Death
Stillbirth
China
Cohort Studies
Logistic Models
Regression Analysis
Logistics

All Science Journal Classification (ASJC) codes

  • Epidemiology
  • Toxicology
  • Pollution
  • Public Health, Environmental and Occupational Health

Cite this

Zhang, Bin ; Liang, Shengwen ; Zhao, Jinzhu ; Qian, Zhengmin ; Bassig, Bryan A. ; Yang, Rong ; Zhang, Yiming ; Hu, Ke ; Xu, Shunqing ; Zheng, Tongzhang ; Yang, Shaoping. / Maternal exposure to air pollutant PM2.5 and PM10 during pregnancy and risk of congenital heart defects. In: Journal of Exposure Science and Environmental Epidemiology. 2016 ; Vol. 26, No. 4. pp. 422-427.
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abstract = "Maternal exposure to ambient air pollution has increasingly been linked to congenital heart defects (CHDs). The objective of this study was to evaluate whether high levels of maternal exposure to PM2.5 and PM10 are related to increased risk of CHDs in Wuhan, China. We conducted a cohort study with a total of 105,988 live-born infants, stillbirths, and fetal deaths. The study included mothers living in the urban district of Wuhan during pregnancy over the 2-year period from 10 June 2011 to 9 June 2013. For each study participant, we assigned 1-month and 1-week averages of PM10 and PM2.5 exposure based on measurements obtained from the nearest exposure monitor to the living residence of mothers during their early pregnancy period. Logistic regression analyses were conducted to calculate the adjusted odds ratios (aORs) and 95{\%} confidence intervals (CI) for the association between exposure to these ambient air pollutants during early pregnancy and CHDs. We observed an increased risk of CHDs, particularly ventricular septal defect (VSD), with increasing PM2.5 exposure. Using 1-week averages, we also observed significant monotonically increasing associations between PM2.5 exposure during weeks 7-10 of pregnancy and risk of VSD, with aORs ranging from 1.11 to 1.17 (95{\%} CI: 1.02-1.20, 1.03-1.22, 1.05-1.24, and 1.08-1.26 separately) per a 10 μg/m3 change in PM2.5 concentration. Our study contributes to the small body of knowledge regarding the association between in utero exposure to air pollution and CHDs, but confirmation of these associations will be needed in future studies.",
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Maternal exposure to air pollutant PM2.5 and PM10 during pregnancy and risk of congenital heart defects. / Zhang, Bin; Liang, Shengwen; Zhao, Jinzhu; Qian, Zhengmin; Bassig, Bryan A.; Yang, Rong; Zhang, Yiming; Hu, Ke; Xu, Shunqing; Zheng, Tongzhang; Yang, Shaoping.

In: Journal of Exposure Science and Environmental Epidemiology, Vol. 26, No. 4, 01.06.2016, p. 422-427.

Research output: Contribution to journalArticle

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