Maternal exposure to ambient air pollutant and risk of oral clefts in Wuhan, China

Jinzhu Zhao, Bin Zhang, Shaoping Yang, Hui Mei, Zhengmin Qian, Shengwen Liang, Yiming Zhang, Ke Hu, Yafei Tan, Hong Xian, Rhonda Belue, Savannah S. Jordan, Shunqing Xu, Tongzhang Zheng, Yukai Du

Research output: Contribution to journalArticle

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Abstract

Maternal exposure to ambient air pollution has been related to oral clefts in offspring; however, the epidemiologic evidence is equivocal. Especially, the association between high levels of exposure to ambient air pollution during pregnancy and oral clefts remains unclear. The objective of this study was to evaluate whether high levels of maternal exposure to PM 2.5 , PM 10 , O 3 , CO and SO 2 are related to increased risk of oral clefts in Wuhan, China. A population-based study was conducted using cohort of 105,927 live-born infants, fetal deaths, and stillbirths during a two-year period from 2011 to 2013. For each participant, weekly and monthly averages of daily mean concentrations for each pollutant were estimated. Multiple logistic regression analyses were constructed to quantify the adjusted odds ratios (aORs) for the relationship between each air pollutant and oral clefts while controlling for key covariates. Using monthly averages, a cleft lip with or without cleft palate (CLP) was associated with PM 2.5 (aORs 2nd month = 1.34, CI:1.19–1.49; aORs 3rd month= 1.14, CI:1.02–1.28), PM 10 (aORs 2nd month = 1.11, CI:1.00–1.23) and CO (aORs 2nd month = 1.31, CI:1.14–1.51; aORs 3rd month = 1.17, CI:1.03–1.33). A cleft palate only (CPO) was associated with PM 2.5 (aORs 2nd month = 1.24, CI: 1.03–1.48), and O 3 (aORs 2nd month = 1.21, CI: 1.03–1.42; aORs 3rd month = 1.18, CI: 1.02–1.37). Our findings reveal an association between air pollutants exposure and the risk of oral clefts. Future studies are needed to confirm these associations, and clarify the causality related to specific pollutants during the most relevant vulnerable exposure time windows for oral clefts during pregnancy.

Original languageEnglish (US)
Pages (from-to)624-630
Number of pages7
JournalEnvironmental Pollution
Volume238
DOIs
StatePublished - Jul 1 2018

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Maternal Exposure
Air Pollutants
Carbon Monoxide
Air pollution
China
Odds Ratio
Air
Logistics
Air Pollution
Cleft Palate
Pregnancy
Fetal Death
Stillbirth
Cleft Lip
Causality
Logistic Models
Regression Analysis

All Science Journal Classification (ASJC) codes

  • Toxicology
  • Pollution
  • Health, Toxicology and Mutagenesis

Cite this

Zhao, Jinzhu ; Zhang, Bin ; Yang, Shaoping ; Mei, Hui ; Qian, Zhengmin ; Liang, Shengwen ; Zhang, Yiming ; Hu, Ke ; Tan, Yafei ; Xian, Hong ; Belue, Rhonda ; Jordan, Savannah S. ; Xu, Shunqing ; Zheng, Tongzhang ; Du, Yukai. / Maternal exposure to ambient air pollutant and risk of oral clefts in Wuhan, China. In: Environmental Pollution. 2018 ; Vol. 238. pp. 624-630.
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title = "Maternal exposure to ambient air pollutant and risk of oral clefts in Wuhan, China",
abstract = "Maternal exposure to ambient air pollution has been related to oral clefts in offspring; however, the epidemiologic evidence is equivocal. Especially, the association between high levels of exposure to ambient air pollution during pregnancy and oral clefts remains unclear. The objective of this study was to evaluate whether high levels of maternal exposure to PM 2.5 , PM 10 , O 3 , CO and SO 2 are related to increased risk of oral clefts in Wuhan, China. A population-based study was conducted using cohort of 105,927 live-born infants, fetal deaths, and stillbirths during a two-year period from 2011 to 2013. For each participant, weekly and monthly averages of daily mean concentrations for each pollutant were estimated. Multiple logistic regression analyses were constructed to quantify the adjusted odds ratios (aORs) for the relationship between each air pollutant and oral clefts while controlling for key covariates. Using monthly averages, a cleft lip with or without cleft palate (CLP) was associated with PM 2.5 (aORs 2nd month = 1.34, CI:1.19–1.49; aORs 3rd month= 1.14, CI:1.02–1.28), PM 10 (aORs 2nd month = 1.11, CI:1.00–1.23) and CO (aORs 2nd month = 1.31, CI:1.14–1.51; aORs 3rd month = 1.17, CI:1.03–1.33). A cleft palate only (CPO) was associated with PM 2.5 (aORs 2nd month = 1.24, CI: 1.03–1.48), and O 3 (aORs 2nd month = 1.21, CI: 1.03–1.42; aORs 3rd month = 1.18, CI: 1.02–1.37). Our findings reveal an association between air pollutants exposure and the risk of oral clefts. Future studies are needed to confirm these associations, and clarify the causality related to specific pollutants during the most relevant vulnerable exposure time windows for oral clefts during pregnancy.",
author = "Jinzhu Zhao and Bin Zhang and Shaoping Yang and Hui Mei and Zhengmin Qian and Shengwen Liang and Yiming Zhang and Ke Hu and Yafei Tan and Hong Xian and Rhonda Belue and Jordan, {Savannah S.} and Shunqing Xu and Tongzhang Zheng and Yukai Du",
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Zhao, J, Zhang, B, Yang, S, Mei, H, Qian, Z, Liang, S, Zhang, Y, Hu, K, Tan, Y, Xian, H, Belue, R, Jordan, SS, Xu, S, Zheng, T & Du, Y 2018, 'Maternal exposure to ambient air pollutant and risk of oral clefts in Wuhan, China', Environmental Pollution, vol. 238, pp. 624-630. https://doi.org/10.1016/j.envpol.2018.03.053

Maternal exposure to ambient air pollutant and risk of oral clefts in Wuhan, China. / Zhao, Jinzhu; Zhang, Bin; Yang, Shaoping; Mei, Hui; Qian, Zhengmin; Liang, Shengwen; Zhang, Yiming; Hu, Ke; Tan, Yafei; Xian, Hong; Belue, Rhonda; Jordan, Savannah S.; Xu, Shunqing; Zheng, Tongzhang; Du, Yukai.

In: Environmental Pollution, Vol. 238, 01.07.2018, p. 624-630.

Research output: Contribution to journalArticle

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T1 - Maternal exposure to ambient air pollutant and risk of oral clefts in Wuhan, China

AU - Zhao, Jinzhu

AU - Zhang, Bin

AU - Yang, Shaoping

AU - Mei, Hui

AU - Qian, Zhengmin

AU - Liang, Shengwen

AU - Zhang, Yiming

AU - Hu, Ke

AU - Tan, Yafei

AU - Xian, Hong

AU - Belue, Rhonda

AU - Jordan, Savannah S.

AU - Xu, Shunqing

AU - Zheng, Tongzhang

AU - Du, Yukai

PY - 2018/7/1

Y1 - 2018/7/1

N2 - Maternal exposure to ambient air pollution has been related to oral clefts in offspring; however, the epidemiologic evidence is equivocal. Especially, the association between high levels of exposure to ambient air pollution during pregnancy and oral clefts remains unclear. The objective of this study was to evaluate whether high levels of maternal exposure to PM 2.5 , PM 10 , O 3 , CO and SO 2 are related to increased risk of oral clefts in Wuhan, China. A population-based study was conducted using cohort of 105,927 live-born infants, fetal deaths, and stillbirths during a two-year period from 2011 to 2013. For each participant, weekly and monthly averages of daily mean concentrations for each pollutant were estimated. Multiple logistic regression analyses were constructed to quantify the adjusted odds ratios (aORs) for the relationship between each air pollutant and oral clefts while controlling for key covariates. Using monthly averages, a cleft lip with or without cleft palate (CLP) was associated with PM 2.5 (aORs 2nd month = 1.34, CI:1.19–1.49; aORs 3rd month= 1.14, CI:1.02–1.28), PM 10 (aORs 2nd month = 1.11, CI:1.00–1.23) and CO (aORs 2nd month = 1.31, CI:1.14–1.51; aORs 3rd month = 1.17, CI:1.03–1.33). A cleft palate only (CPO) was associated with PM 2.5 (aORs 2nd month = 1.24, CI: 1.03–1.48), and O 3 (aORs 2nd month = 1.21, CI: 1.03–1.42; aORs 3rd month = 1.18, CI: 1.02–1.37). Our findings reveal an association between air pollutants exposure and the risk of oral clefts. Future studies are needed to confirm these associations, and clarify the causality related to specific pollutants during the most relevant vulnerable exposure time windows for oral clefts during pregnancy.

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