Maternal nutritional status in early pregnancy is associated with body water and plasma volume changes in a pregnancy cohort in rural Bangladesh

Alison Diane Gernand, Parul Christian, Kerry J. Schulze, Saijuddin Shaikh, Alain B. Labrique, Abu Ahmed Shamim, Keith P. West

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10 Citations (Scopus)

Abstract

Plasma volume expansion has been associated with fetal growth. Our objective was to examine the associations between maternal nutritional status in early pregnancy and extracellular water (ECW), total body water (TBW), and percentage plasma volume change across pregnancy. In a subsample of 377 pregnant women participating in a cluster-randomized trial of micronutrient supplementation, hemoglobin, hematocrit, and multi-frequency bioelectrical impedance were measured at ~ 10, 20, and 32 wk of gestation. In early pregnancy, women were short (mean ± SD, 148.9 ± 5.3 cm) and thin (19.5 ± 2.5 kg/m2). In mixed-effects multiple regression models, a 1-unit higher BMI ~ 10 wk was associated with higher ECW and TBW (0.27 and 0.66 kg per kg/m2, respectively; P < 0.01) at ~ 10, ~20, and ~32 wk. Height was also positively associated with ECW and TBW at each time point. Early pregnancy BMI was negatively associated with gains in ECW and TBW (20.06 and 20.14 kg per kg/m2, respectively; P < 0.01) from 10 to 20 wk, but not with 20- to 32-wk gains after accounting for weight gain. BMI was positively associated with percentage changes in plasma volume from 20 to 32 wk (0.57% per kg/m2; P < 0.05). Height was not associated with changes in body water or plasma volume. Women with low BMI and height in early pregnancy have lower ECW and TBWin early,mid, and late pregnancy and lower late pregnancy plasma volume expansion, potentially increasing risk of fetal growth restriction.

Original languageEnglish (US)
Pages (from-to)1109-1115
Number of pages7
JournalJournal of Nutrition
Volume142
Issue number6
DOIs
StatePublished - Jun 1 2012

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Bangladesh
Body Water
Plasma Volume
Nutritional Status
Mothers
Pregnancy
Water
Fetal Development
Micronutrients
Electric Impedance
Hematocrit
Weight Gain
Pregnant Women
Hemoglobins

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Gernand, Alison Diane ; Christian, Parul ; Schulze, Kerry J. ; Shaikh, Saijuddin ; Labrique, Alain B. ; Shamim, Abu Ahmed ; West, Keith P. / Maternal nutritional status in early pregnancy is associated with body water and plasma volume changes in a pregnancy cohort in rural Bangladesh. In: Journal of Nutrition. 2012 ; Vol. 142, No. 6. pp. 1109-1115.
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abstract = "Plasma volume expansion has been associated with fetal growth. Our objective was to examine the associations between maternal nutritional status in early pregnancy and extracellular water (ECW), total body water (TBW), and percentage plasma volume change across pregnancy. In a subsample of 377 pregnant women participating in a cluster-randomized trial of micronutrient supplementation, hemoglobin, hematocrit, and multi-frequency bioelectrical impedance were measured at ~ 10, 20, and 32 wk of gestation. In early pregnancy, women were short (mean ± SD, 148.9 ± 5.3 cm) and thin (19.5 ± 2.5 kg/m2). In mixed-effects multiple regression models, a 1-unit higher BMI ~ 10 wk was associated with higher ECW and TBW (0.27 and 0.66 kg per kg/m2, respectively; P < 0.01) at ~ 10, ~20, and ~32 wk. Height was also positively associated with ECW and TBW at each time point. Early pregnancy BMI was negatively associated with gains in ECW and TBW (20.06 and 20.14 kg per kg/m2, respectively; P < 0.01) from 10 to 20 wk, but not with 20- to 32-wk gains after accounting for weight gain. BMI was positively associated with percentage changes in plasma volume from 20 to 32 wk (0.57{\%} per kg/m2; P < 0.05). Height was not associated with changes in body water or plasma volume. Women with low BMI and height in early pregnancy have lower ECW and TBWin early,mid, and late pregnancy and lower late pregnancy plasma volume expansion, potentially increasing risk of fetal growth restriction.",
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Maternal nutritional status in early pregnancy is associated with body water and plasma volume changes in a pregnancy cohort in rural Bangladesh. / Gernand, Alison Diane; Christian, Parul; Schulze, Kerry J.; Shaikh, Saijuddin; Labrique, Alain B.; Shamim, Abu Ahmed; West, Keith P.

In: Journal of Nutrition, Vol. 142, No. 6, 01.06.2012, p. 1109-1115.

Research output: Contribution to journalArticle

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