TY - JOUR
T1 - Maternal urinary cadmium concentrations in relation to preterm birth in the Healthy Baby Cohort Study in China
AU - Yang, Jie
AU - Huo, Wenqian
AU - Zhang, Bin
AU - Zheng, Tongzhang
AU - Li, Yuanyuan
AU - Pan, Xinyun
AU - Liu, Wenyu
AU - Chang, Huailong
AU - Jiang, Minmin
AU - Zhou, Aifen
AU - Qian, Zhengmin
AU - Wan, Yanjian
AU - Xia, Wei
AU - Xu, Shunqing
N1 - Funding Information:
We are grateful to all the participants for providing the urine samples and collaborators for their great effort in the cohort study. This work was supported by the National Natural Science Foundation of China ( 21437002 , 81372959 , 81402649 ), the R&D Special Fund for Public Welfare Industry (Environment) ( 201309048 ), the Fundamental Research Funds for the Central Universities, HUST ( 2016YXZD043 ), and the National Basic Research Program of China (973 Program) ( 2012CB722401 ).
Publisher Copyright:
© 2016
Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2016/9/1
Y1 - 2016/9/1
N2 - Background Prenatal cadmium (Cd) exposure has been associated with adverse birth outcomes, but the findings of previous studies are inconsistent. The aim of this study was to evaluate the association between prenatal Cd exposure and birth outcomes. Methods This study was conducted in 5364 pregnant women with a live singleton birth, who were recruited between September 2012 and October 2014 in the Healthy Baby Cohort (HBC) in Wuhan, China. Gestational age (in days) was estimated using both the woman's last menstrual period (LMP) and ultrasound data. All the birth outcomes including birth weight and birth length were measured in the hospital within one hour after birth through standardized procedures. Cd was measured in maternal urine collected before delivery with inductively coupled plasma mass spectrometry. Results The geometric mean of Cd concentration in maternal urine was 0.55 (range 0.01–2.85) μg/g creatinine. We found each ln-unit increase in Cd concentration (μg/g creatinine) in maternal urine was associated with decreased gestational age [adjusted β = − 0.77 day; 95% confidence interval (CI): − 1.15, − 0.39 for all infants; − 0.77; 95% CI: − 1.29, − 0.25 for boys; and − 0.80; 95% CI: − 1.35, − 0.25 for girls]. Increased likelihood of preterm birth (PTB) was associated with ln-unit increase in urinary Cd (μg/g creatinine) [adjusted odds ratio (OR) = 1.78; 95% CI: 1.45, 2.19 for all infants; 1.97; 95% CI: 1.46, 2.65 for boys; and 1.67; 95% CI: 1.24, 2.25 for girls]. Maternal urinary Cd was not significantly associated with low birth weight (LBW) and small for gestational age (SGA). Conclusions Maternal exposure to Cd during pregnancy was associated with decreased gestational age and increased likelihood of PTB.
AB - Background Prenatal cadmium (Cd) exposure has been associated with adverse birth outcomes, but the findings of previous studies are inconsistent. The aim of this study was to evaluate the association between prenatal Cd exposure and birth outcomes. Methods This study was conducted in 5364 pregnant women with a live singleton birth, who were recruited between September 2012 and October 2014 in the Healthy Baby Cohort (HBC) in Wuhan, China. Gestational age (in days) was estimated using both the woman's last menstrual period (LMP) and ultrasound data. All the birth outcomes including birth weight and birth length were measured in the hospital within one hour after birth through standardized procedures. Cd was measured in maternal urine collected before delivery with inductively coupled plasma mass spectrometry. Results The geometric mean of Cd concentration in maternal urine was 0.55 (range 0.01–2.85) μg/g creatinine. We found each ln-unit increase in Cd concentration (μg/g creatinine) in maternal urine was associated with decreased gestational age [adjusted β = − 0.77 day; 95% confidence interval (CI): − 1.15, − 0.39 for all infants; − 0.77; 95% CI: − 1.29, − 0.25 for boys; and − 0.80; 95% CI: − 1.35, − 0.25 for girls]. Increased likelihood of preterm birth (PTB) was associated with ln-unit increase in urinary Cd (μg/g creatinine) [adjusted odds ratio (OR) = 1.78; 95% CI: 1.45, 2.19 for all infants; 1.97; 95% CI: 1.46, 2.65 for boys; and 1.67; 95% CI: 1.24, 2.25 for girls]. Maternal urinary Cd was not significantly associated with low birth weight (LBW) and small for gestational age (SGA). Conclusions Maternal exposure to Cd during pregnancy was associated with decreased gestational age and increased likelihood of PTB.
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U2 - 10.1016/j.envint.2016.06.003
DO - 10.1016/j.envint.2016.06.003
M3 - Article
C2 - 27289180
AN - SCOPUS:84977110573
VL - 94
SP - 300
EP - 306
JO - Environmental International
JF - Environmental International
SN - 0160-4120
ER -