Maternal viral genotypic zidovudine (ZDV) resistance and infrequent failure of ZDV therapy to prevent perinatal transmission

R. W. Coombs, D. E. Shapiro, P. S. Eastman, L. M. Frenkel, George McSherry, P. Britto, S. A. Herman, R. S. Sperling

Research output: Contribution to journalArticle

Abstract

To assess the importance of ZDV resistance on mother-to-infant transmission we evaluated maternal plasma specimens from 96 women enrolled in ACTG protocol 076 to determine the prevalence of HIV-1 genotypic ZDV resistance at entry, if ZDV resistance developed on study, and the role of ZDV resistance in vertical transmission of HIV-1 despite ZDV therapy. Low and high levels of genotypic resistance were assessed by differential hybridization, oligoligation or direct sequencing of plasma HIV-1 RNA for codons K70R and T215Y/F, respectively. None of the women had high-level genotypic resistance to ZDV at study entry or at delivery. The upper 97.5% confidence limits for baseline prevalence and delivery incidence of low-level ZDV resistance were 6.8% and 14.0%, respectively. After adjusting for the plasma HIV-1 RNA level at delivery, low-level ZDV resistance was not strongly associated with an increase in vertical transmission risk (odds ration 4.8; 95% CI 0.2-131; P = . 35) . Infrequent failure of ZDV to prevent vertical transmission to some infants was not explained by the presence of maternal virus with genotypic ZDV resistance.

Original languageEnglish (US)
Number of pages1
JournalClinical Infectious Diseases
Volume25
Issue number2
StatePublished - Dec 1 1997

All Science Journal Classification (ASJC) codes

  • Microbiology (medical)
  • Infectious Diseases

Fingerprint Dive into the research topics of 'Maternal viral genotypic zidovudine (ZDV) resistance and infrequent failure of ZDV therapy to prevent perinatal transmission'. Together they form a unique fingerprint.

  • Cite this

    Coombs, R. W., Shapiro, D. E., Eastman, P. S., Frenkel, L. M., McSherry, G., Britto, P., Herman, S. A., & Sperling, R. S. (1997). Maternal viral genotypic zidovudine (ZDV) resistance and infrequent failure of ZDV therapy to prevent perinatal transmission. Clinical Infectious Diseases, 25(2).