Maternal Weight and Body Composition during Pregnancy Are Associated with Placental and Birth Weight in Rural Bangladesh1,2

Alison D. Gernand, Parul Christian, Rina Rani Paul, Saijuddin Shaikh, Alain B. Labrique, Kerry J. Schulze, Abu Ahmed Shamim, Keith P. West

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23 Scopus citations

Abstract

Placental growth is a strong predictor of fetal growth, but little is known about maternal predictors of placental growth in malnourished populations. Our objective was to investigate in a prospective study the associations of maternal weight and body composition [total body water (TBW) estimated by bioelectrical impedance and fat and fat-free mass derived from upper arm fat and muscle areas (UAFA, UAMA)] and changes in these with placental and birth weights. Within a cluster- randomized trial of maternal micronutrient supplementation, a subsample of 350 women was measured 3 times across gestation. Longitudinal analysis was used to examine independent associations of;10-wk measurements and;10-20wk and;20-32wk changes with birth outcomes. Weight, TBW, and UAMA, but not UAFA, at;10wk were each positively and independently associated with placental weight and birth weight (P < 0.05). Of the maternal;10-20wk changes in measurements, only TBW change and placental weight, and maternal weight and birth weight were positively associated (P < 0.05). Gains in weight, TBW, and UAMA from 20 to 32wk were positively and UAFA gain was negatively associated with placental weight (P # 0.01). Gains in weight and UAMA from 20 to 32wk were positively associated with birth weight (P # 0.01). Overall, higher maternal weight and measures of fat-free mass at;10wk gestation and gains from 20 to 32wk are independently associated with higher placental and birth weight.

Original languageEnglish (US)
Pages (from-to)2010-2016
Number of pages7
JournalJournal of Nutrition
Volume142
Issue number11
DOIs
StatePublished - Nov 1 2012

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All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Gernand, A. D., Christian, P., Paul, R. R., Shaikh, S., Labrique, A. B., Schulze, K. J., Shamim, A. A., & West, K. P. (2012). Maternal Weight and Body Composition during Pregnancy Are Associated with Placental and Birth Weight in Rural Bangladesh1,2. Journal of Nutrition, 142(11), 2010-2016. https://doi.org/10.3945/jn.112.163634