Mathematical model of sarcoidosis

Wenrui Hao; Elliott D. Crouser; Avner Friedman

doi:10.1073/pnas.1417789111

Mathematical model of sarcoidosis

Wenrui Hao, Elliott D. Crouser, Avner Friedman

Research output: Contribution to journal › Article › peer-review

32 Scopus citations

Abstract

Sarcoidosis is a disease involving abnormal collection of inflammatory cells forming nodules, called granulomas. Such granulomas occur in the lung and the mediastinal lymph nodes, in the heart, and in other vital and nonvital organs. The origin of the disease is unknown, and there are only limited clinical data on lung tissue of patients. No current model of sarcoidosis exists. In this paper we develop a mathematical model on the dynamics of the disease in the lung and use patients' lung tissue data to validate the model. The model is used to explore potential treatments.

Original language	English (US)
Pages (from-to)	16065-16070
Number of pages	6
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	111
Issue number	45
DOIs	https://doi.org/10.1073/pnas.1417789111
State	Published - Nov 11 2014

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abstract = "Sarcoidosis is a disease involving abnormal collection of inflammatory cells forming nodules, called granulomas. Such granulomas occur in the lung and the mediastinal lymph nodes, in the heart, and in other vital and nonvital organs. The origin of the disease is unknown, and there are only limited clinical data on lung tissue of patients. No current model of sarcoidosis exists. In this paper we develop a mathematical model on the dynamics of the disease in the lung and use patients' lung tissue data to validate the model. The model is used to explore potential treatments.",

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AU - Crouser, Elliott D.

AU - Friedman, Avner

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AB - Sarcoidosis is a disease involving abnormal collection of inflammatory cells forming nodules, called granulomas. Such granulomas occur in the lung and the mediastinal lymph nodes, in the heart, and in other vital and nonvital organs. The origin of the disease is unknown, and there are only limited clinical data on lung tissue of patients. No current model of sarcoidosis exists. In this paper we develop a mathematical model on the dynamics of the disease in the lung and use patients' lung tissue data to validate the model. The model is used to explore potential treatments.

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Mathematical model of sarcoidosis

Abstract

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