Mathematical modeling of material-induced blood plasma coagulation

Zhe Guo; Karen M. Bussard; Kaushik Chatterjee; Rachel Miller; Erwin A. Vogler; Christopher A. Siedlecki

doi:10.1016/j.biomaterials.2005.06.021

Mathematical modeling of material-induced blood plasma coagulation

Zhe Guo, Karen M. Bussard, Kaushik Chatterjee, Rachel Miller, Erwin A. Vogler, Christopher A. Siedlecki

Research output: Contribution to journal › Article › peer-review

49 Scopus citations

Abstract

Contact activation of the intrinsic pathway of the blood coagulation cascade is initiated when a procoagulant material interacts with coagulation factor XII, (FXII) yielding a proteolytic enzyme FXIIa. Procoagulant surface properties are thought to play an important role in activation. To study the mechanism of interaction between procoagulant materials and blood plasma, a mathematical model that is similar in form and in derivation to Michaelis-Menten enzyme kinetics was developed in order to yield tractable relationships between dose (surface area and energy) and response (coagulation time (CT)). The application of this model to experimental data suggests that CT is dependent on the FXIIa concentration and that the amount of FXIIa generated can be analyzed using a model that is linearly dependent on contact time. It is concluded from these experiments and modeling analysis that the primary mechanism for activation of coagulation involves autoactivation of FXII by the procoagulant surface or kallikrein-mediated reciprocal activation of FXII. FXIIa-induced self-amplification of FXII is insignificant.

Original language	English (US)
Pages (from-to)	796-806
Number of pages	11
Journal	Biomaterials
Volume	27
Issue number	5
DOIs	https://doi.org/10.1016/j.biomaterials.2005.06.021
State	Published - Feb 2006

All Science Journal Classification (ASJC) codes

Bioengineering
Ceramics and Composites
Biophysics
Biomaterials
Mechanics of Materials

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10.1016/j.biomaterials.2005.06.021

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title = "Mathematical modeling of material-induced blood plasma coagulation",

abstract = "Contact activation of the intrinsic pathway of the blood coagulation cascade is initiated when a procoagulant material interacts with coagulation factor XII, (FXII) yielding a proteolytic enzyme FXIIa. Procoagulant surface properties are thought to play an important role in activation. To study the mechanism of interaction between procoagulant materials and blood plasma, a mathematical model that is similar in form and in derivation to Michaelis-Menten enzyme kinetics was developed in order to yield tractable relationships between dose (surface area and energy) and response (coagulation time (CT)). The application of this model to experimental data suggests that CT is dependent on the FXIIa concentration and that the amount of FXIIa generated can be analyzed using a model that is linearly dependent on contact time. It is concluded from these experiments and modeling analysis that the primary mechanism for activation of coagulation involves autoactivation of FXII by the procoagulant surface or kallikrein-mediated reciprocal activation of FXII. FXIIa-induced self-amplification of FXII is insignificant.",

author = "Zhe Guo and Bussard, {Karen M.} and Kaushik Chatterjee and Rachel Miller and Vogler, {Erwin A.} and Siedlecki, {Christopher A.}",

note = "Funding Information: Financial support for this work was provided by the National Institutes of Health (RO1 HL69965). ",

year = "2006",

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doi = "10.1016/j.biomaterials.2005.06.021",

language = "English (US)",

volume = "27",

pages = "796--806",

journal = "Biomaterials",

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T1 - Mathematical modeling of material-induced blood plasma coagulation

AU - Guo, Zhe

AU - Bussard, Karen M.

AU - Chatterjee, Kaushik

AU - Miller, Rachel

AU - Vogler, Erwin A.

AU - Siedlecki, Christopher A.

N1 - Funding Information: Financial support for this work was provided by the National Institutes of Health (RO1 HL69965).

PY - 2006/2

Y1 - 2006/2

N2 - Contact activation of the intrinsic pathway of the blood coagulation cascade is initiated when a procoagulant material interacts with coagulation factor XII, (FXII) yielding a proteolytic enzyme FXIIa. Procoagulant surface properties are thought to play an important role in activation. To study the mechanism of interaction between procoagulant materials and blood plasma, a mathematical model that is similar in form and in derivation to Michaelis-Menten enzyme kinetics was developed in order to yield tractable relationships between dose (surface area and energy) and response (coagulation time (CT)). The application of this model to experimental data suggests that CT is dependent on the FXIIa concentration and that the amount of FXIIa generated can be analyzed using a model that is linearly dependent on contact time. It is concluded from these experiments and modeling analysis that the primary mechanism for activation of coagulation involves autoactivation of FXII by the procoagulant surface or kallikrein-mediated reciprocal activation of FXII. FXIIa-induced self-amplification of FXII is insignificant.

AB - Contact activation of the intrinsic pathway of the blood coagulation cascade is initiated when a procoagulant material interacts with coagulation factor XII, (FXII) yielding a proteolytic enzyme FXIIa. Procoagulant surface properties are thought to play an important role in activation. To study the mechanism of interaction between procoagulant materials and blood plasma, a mathematical model that is similar in form and in derivation to Michaelis-Menten enzyme kinetics was developed in order to yield tractable relationships between dose (surface area and energy) and response (coagulation time (CT)). The application of this model to experimental data suggests that CT is dependent on the FXIIa concentration and that the amount of FXIIa generated can be analyzed using a model that is linearly dependent on contact time. It is concluded from these experiments and modeling analysis that the primary mechanism for activation of coagulation involves autoactivation of FXII by the procoagulant surface or kallikrein-mediated reciprocal activation of FXII. FXIIa-induced self-amplification of FXII is insignificant.

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JO - Biomaterials

JF - Biomaterials

SN - 0142-9612

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Mathematical modeling of material-induced blood plasma coagulation

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