Maturation of a central glutamatergic synapse

Gangyi Wu, R. Malinow, H. T. Cline

Research output: Contribution to journalArticle

427 Citations (Scopus)

Abstract

Whole-cell recordings from optic tectal neurons in Xenopus tadpoles were used to study the maturation of a glutamatergic synapse. The first glutamatergic transmission is mediated only by N-methyl-D-aspartate (NMDA) receptors and is silent at resting potentials. More mature synapses acquire transmission by α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptors. This maturational program is mimicked by postsynaptic expression of constitutively active calcium-calmodulin-dependent protein kinase II (CaMKII). Newly formed synapses may be silent unless sufficient depolarization is provided by coincident activity that could activate postsynaptic CaMKII, resulting in the appearance of AMPA responses.

Original languageEnglish (US)
Pages (from-to)972-976
Number of pages5
JournalScience
Volume274
Issue number5289
DOIs
StatePublished - Nov 8 1996

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Calcium-Calmodulin-Dependent Protein Kinase Type 2
Synapses
Isoxazoles
Calcium-Calmodulin-Dependent Protein Kinases
alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid
AMPA Receptors
Patch-Clamp Techniques
Xenopus
N-Methyl-D-Aspartate Receptors
Membrane Potentials
Larva
Neurons

All Science Journal Classification (ASJC) codes

  • General

Cite this

Wu, G., Malinow, R., & Cline, H. T. (1996). Maturation of a central glutamatergic synapse. Science, 274(5289), 972-976. https://doi.org/10.1126/science.274.5289.972
Wu, Gangyi ; Malinow, R. ; Cline, H. T. / Maturation of a central glutamatergic synapse. In: Science. 1996 ; Vol. 274, No. 5289. pp. 972-976.
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Wu, G, Malinow, R & Cline, HT 1996, 'Maturation of a central glutamatergic synapse', Science, vol. 274, no. 5289, pp. 972-976. https://doi.org/10.1126/science.274.5289.972

Maturation of a central glutamatergic synapse. / Wu, Gangyi; Malinow, R.; Cline, H. T.

In: Science, Vol. 274, No. 5289, 08.11.1996, p. 972-976.

Research output: Contribution to journalArticle

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