Measuring and quantifying skin sympathetic nervous system activity in humans

Jody Leigh Greaney, William Lawrence Kenney, Jr.

Research output: Contribution to journalReview article

2 Citations (Scopus)

Abstract

Development of the technique of microneurography has substantially increased our understanding of the function of the sympathetic nervous system (SNS) in health and in disease. The ability to directly record signals from peripheral autonomic nerves in conscious humans allows for qualitative and quantitative characterization of SNS responses to specific stimuli and over time. Furthermore, distinct neural outflow to muscle (MSNA) and skin (SSNA) can be delineated. However, there are limitations and caveats to the use of microneurography, measurement criteria, and signal analysis and interpretation. MSNA recordings have a longer history and are considered relatively more straightforward from a measurement and analysis perspective. This brief review provides an overview of the development of the technique as used to measure SSNA. The focus is on the utility of measuring sympathetic activity directed to the skin, the unique issues related to analyzing and quantifying multiunit SSNA, and the challenges related to its interpretation.

Original languageEnglish (US)
Pages (from-to)2181-2193
Number of pages13
JournalJournal of neurophysiology
Volume118
Issue number4
DOIs
StatePublished - Oct 1 2017

Fingerprint

Sympathetic Nervous System
Human Activities
Autonomic Pathways
Skin
Peripheral Nerves
History
Muscles
Health

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Physiology

Cite this

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abstract = "Development of the technique of microneurography has substantially increased our understanding of the function of the sympathetic nervous system (SNS) in health and in disease. The ability to directly record signals from peripheral autonomic nerves in conscious humans allows for qualitative and quantitative characterization of SNS responses to specific stimuli and over time. Furthermore, distinct neural outflow to muscle (MSNA) and skin (SSNA) can be delineated. However, there are limitations and caveats to the use of microneurography, measurement criteria, and signal analysis and interpretation. MSNA recordings have a longer history and are considered relatively more straightforward from a measurement and analysis perspective. This brief review provides an overview of the development of the technique as used to measure SSNA. The focus is on the utility of measuring sympathetic activity directed to the skin, the unique issues related to analyzing and quantifying multiunit SSNA, and the challenges related to its interpretation.",
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Measuring and quantifying skin sympathetic nervous system activity in humans. / Greaney, Jody Leigh; Kenney, Jr., William Lawrence.

In: Journal of neurophysiology, Vol. 118, No. 4, 01.10.2017, p. 2181-2193.

Research output: Contribution to journalReview article

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AU - Kenney, Jr., William Lawrence

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