Measuring European population stratification with microarray genotype data

Marc Bauchet, Brian McEvoy, Laurel N. Pearson, Ellen E. Quillen, Tamara Sarkisian, Kristine Hovhannesyan, Ranjan Deka, Daniel G. Bradley, Mark D. Shriver

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Abstract

A proper understanding of population genetic stratification - differences in individual ancestry within a population - is crucial in attempts to find genes for complex traits through association mapping. We report on genomewide typing of ∼10,000 single-nucleotide polymorphisms in 297 individuals, to explore population structure in Europeans of known and unknown ancestry. The results reveal the presence of several significant axes of stratification, most prominently in a northern-southeastern trend, but also along an east-west axis. We also demonstrate the selection and application of EuroAIMs (European ancestry informative markers) for ancestry estimation and correction. The Coriell Caucasian and CEPH (Centre d'Étude du Polymorphisme Humain) Utah sample panels, often used as proxies for European populations, are found to reflect different subsets of the continent's ancestry.

Original languageEnglish (US)
Pages (from-to)948-956
Number of pages9
JournalAmerican Journal of Human Genetics
Volume80
Issue number5
DOIs
StatePublished - May 2007

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All Science Journal Classification (ASJC) codes

  • Genetics
  • Genetics(clinical)

Cite this

Bauchet, M., McEvoy, B., Pearson, L. N., Quillen, E. E., Sarkisian, T., Hovhannesyan, K., Deka, R., Bradley, D. G., & Shriver, M. D. (2007). Measuring European population stratification with microarray genotype data. American Journal of Human Genetics, 80(5), 948-956. https://doi.org/10.1086/513477