Mechanical restriction of intracortical vessel dilation by brain tissue sculpts the hemodynamic response

Yu Rong Gao, Stephanie E. Greene, Patrick James Drew

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Understanding the spatial dynamics of dilation in the cerebral vasculature is essential for deciphering the vascular basis of hemodynamic signals in the brain. We used two-photon microscopy to image neural activity and vascular dynamics in the somatosensory cortex of awake behaving mice during voluntary locomotion. Arterial dilations within the histologically-defined forelimb/hindlimb (FL/HL) representation were larger than arterial dilations in the somatosensory cortex immediately outside the FL/HL representation, demonstrating that the vascular response during natural behaviors was spatially localized. Surprisingly, we found that locomotion drove dilations in surface vessels that were nearly three times the amplitude of intracortical vessel dilations. The smaller dilations of the intracortical arterioles were not due to saturation of dilation. Anatomical imaging revealed that, unlike surface vessels, intracortical vessels were tightly enclosed by brain tissue. A mathematical model showed that mechanical restriction by the brain tissue surrounding intracortical vessels could account for the reduced amplitude of intracortical vessel dilation relative to surface vessels. Thus, under normal conditions, the mechanical properties of the brain may play an important role in sculpting the laminar differences of hemodynamic responses.

Original languageEnglish (US)
Pages (from-to)162-176
Number of pages15
JournalNeuroImage
Volume115
DOIs
StatePublished - Jul 5 2015

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Dilatation
Hemodynamics
Brain
Blood Vessels
Somatosensory Cortex
Forelimb
Locomotion
Hindlimb
Arterioles
Photons
Microscopy
Theoretical Models

All Science Journal Classification (ASJC) codes

  • Neurology
  • Cognitive Neuroscience

Cite this

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Mechanical restriction of intracortical vessel dilation by brain tissue sculpts the hemodynamic response. / Gao, Yu Rong; Greene, Stephanie E.; Drew, Patrick James.

In: NeuroImage, Vol. 115, 05.07.2015, p. 162-176.

Research output: Contribution to journalArticle

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