TY - GEN
T1 - MECHANICS OF CELL ROLLING ADHESION IN SHEAR FLOW
AU - Lei, Xiaoxiao
AU - Lawrence, Michael B.
AU - Dong, Cheng
N1 - Funding Information:
Supported by Whitaker Foundation (CD), National Science Foundation (BES-9502067) (CD), and NIH (HL54614) (MBL).
Funding Information:
Supported by Whitaker Foundation (CD), National Science
Publisher Copyright:
© 1997 American Society of Mechanical Engineers (ASME). All rights reserved.
PY - 1997
Y1 - 1997
N2 - Leukocyte rolling along endothelial cells is a critical step of leukocyte-endothelium interaction, which plays important roles in tissue inflammation and wound healing [1]. The occurrence of rolling results from the dynamic balance of hemodynamic shearing force acting on the cell and adhesive bond force between cell and endothelium, while the balance strongly depends on the leukocyte deformability [2]. The objective of this study is to elucidate the effects of (1) hydrodynamic shear stress, (2) cell deformation, and (3) surface adhesion strength on the rolling adhesion event through in vitro experiment and theoretical simulation.
AB - Leukocyte rolling along endothelial cells is a critical step of leukocyte-endothelium interaction, which plays important roles in tissue inflammation and wound healing [1]. The occurrence of rolling results from the dynamic balance of hemodynamic shearing force acting on the cell and adhesive bond force between cell and endothelium, while the balance strongly depends on the leukocyte deformability [2]. The objective of this study is to elucidate the effects of (1) hydrodynamic shear stress, (2) cell deformation, and (3) surface adhesion strength on the rolling adhesion event through in vitro experiment and theoretical simulation.
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U2 - 10.1115/IMECE1997-0284
DO - 10.1115/IMECE1997-0284
M3 - Conference contribution
AN - SCOPUS:85126929555
T3 - ASME International Mechanical Engineering Congress and Exposition, Proceedings (IMECE)
SP - 173
EP - 174
BT - Advances in Bioengineering
PB - American Society of Mechanical Engineers (ASME)
T2 - ASME 1997 International Mechanical Engineering Congress and Exposition, IMECE 1997 - Advances in Bioengineering
Y2 - 16 November 1997 through 21 November 1997
ER -