Mechanics of white blood cell and endothelium adhesion

Cheng Dong, Jian Cao, Xiao X. Lei, Herbert Herling Lipowsky

Research output: Contribution to conferencePaper

1 Scopus citations

Abstract

The mechanics of white blood cell (WBC) deformation and adhesion to the vascular endothelium (EC) in shear flow has been previously studied in the light of WBC biophysical properties. Microscopic images reveal that for a given wall shear stress, contact area increases with time as new bonds are formed at the leading edge, and then decreases with time as the trailing edge of the WBC membrane peels away from the EC. In this paper, the kinetics of WBC-EC adhesion and the extent of WBC shape change due to cell deformation during adhesive process are studied. The relative influence of WBC deformability and adhesion kinetics on the bonding and peeling of the WBC and EC are described using a simple biophysical model.

Original languageEnglish (US)
Pages459-460
Number of pages2
StatePublished - Jan 1 1995
EventProceedings of the 1995 Bioengineering Conference - Beever Creek, CO, USA
Duration: Jun 28 1995Jul 2 1995

Other

OtherProceedings of the 1995 Bioengineering Conference
CityBeever Creek, CO, USA
Period6/28/957/2/95

    Fingerprint

All Science Journal Classification (ASJC) codes

  • Engineering(all)

Cite this

Dong, C., Cao, J., Lei, X. X., & Lipowsky, H. H. (1995). Mechanics of white blood cell and endothelium adhesion. 459-460. Paper presented at Proceedings of the 1995 Bioengineering Conference, Beever Creek, CO, USA, .