Mechanism and Role of Globin-Coupled Sensor Signalling

Johnnie A. Walker, Shannon Rivera, Emily E. Weinert

Research output: Chapter in Book/Report/Conference proceedingChapter

6 Citations (Scopus)

Abstract

The discovery of the globin-coupled sensor (GCS) family of haem proteins has provided new insights into signalling proteins and pathways by which organisms sense and respond to changing oxygen levels. GCS proteins consist of a sensor globin domain linked to a variety of output domains, suggesting roles in controlling numerous cellular pathways, and behaviours in response to changing oxygen concentration. Members of this family of proteins have been identified in the genomes of numerous organisms and characterization of GCS with output domains, including methyl accepting chemotaxis proteins, kinases, and diguanylate cyclases, have yielded an understanding of the mechanism by which oxygen controls activity of GCS protein output domains, as well as downstream proteins and pathways regulated by GCS signalling. Future studies will expand our understanding of these proteins both in vitro and in vivo, likely demonstrating broad roles for GCS in controlling oxygen-dependent microbial physiology and phenotypes.

Original languageEnglish (US)
Title of host publicationAdvances in Microbial Physiology
PublisherAcademic Press
Pages133-169
Number of pages37
DOIs
StatePublished - Jan 1 2017

Publication series

NameAdvances in Microbial Physiology
Volume71
ISSN (Print)0065-2911

Fingerprint

Globins
Oxygen
Proteins
Heme
Protein Kinases
Genome
Phenotype

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Physiology

Cite this

Walker, J. A., Rivera, S., & Weinert, E. E. (2017). Mechanism and Role of Globin-Coupled Sensor Signalling. In Advances in Microbial Physiology (pp. 133-169). (Advances in Microbial Physiology; Vol. 71). Academic Press. https://doi.org/10.1016/bs.ampbs.2017.05.003
Walker, Johnnie A. ; Rivera, Shannon ; Weinert, Emily E. / Mechanism and Role of Globin-Coupled Sensor Signalling. Advances in Microbial Physiology. Academic Press, 2017. pp. 133-169 (Advances in Microbial Physiology).
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Walker, JA, Rivera, S & Weinert, EE 2017, Mechanism and Role of Globin-Coupled Sensor Signalling. in Advances in Microbial Physiology. Advances in Microbial Physiology, vol. 71, Academic Press, pp. 133-169. https://doi.org/10.1016/bs.ampbs.2017.05.003

Mechanism and Role of Globin-Coupled Sensor Signalling. / Walker, Johnnie A.; Rivera, Shannon; Weinert, Emily E.

Advances in Microbial Physiology. Academic Press, 2017. p. 133-169 (Advances in Microbial Physiology; Vol. 71).

Research output: Chapter in Book/Report/Conference proceedingChapter

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Walker JA, Rivera S, Weinert EE. Mechanism and Role of Globin-Coupled Sensor Signalling. In Advances in Microbial Physiology. Academic Press. 2017. p. 133-169. (Advances in Microbial Physiology). https://doi.org/10.1016/bs.ampbs.2017.05.003