Mechanism of incomplete mitral leaflet coaptation - Interaction of chordal restraint and changes in mitral leaflet coaptation geometry: Insight from in vitro validation of the premise of force equilibrium

Sten Lyager Nielsen, Hans Nygaard, Lars Mandrup, Arnold A. Fontaine, J. Michael Hasenkam, Shengqui He, Ajit P. Yoganathan

Research output: Contribution to journalArticlepeer-review

32 Scopus citations

Abstract

Clinically observed incomplete mitral leaflet coaptation was reproduced in vitro by altering the balance of the chordal tethering and chordal coapting force components. Mitral leaflet coaptation geometry was distorted by changes of the spatial relations between the papillary muscles and the mitral valve as well as hemodynamics. Mitral leaflet malalignment was accentuated by a redistribution of the chordal tethering and coapting force components. For the overall assessment of systolic mitral leaflet configuration in functional mitral regurgitation it is important to consider the interaction between chordal restraint and an altered mitral leaflet coaptation geometry.

Original languageEnglish (US)
Pages (from-to)596-608
Number of pages13
JournalJournal of Biomechanical Engineering
Volume124
Issue number5
DOIs
StatePublished - Oct 2002

All Science Journal Classification (ASJC) codes

  • Biomedical Engineering
  • Physiology (medical)

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