Mechanism of remote myocardial ischaemia after coronary occlusion in open chest dogs

Joseph Gascho, Terry L. Flanagan, C. Foster Jennings, George A. Beller

Research output: Contribution to journalReview article

2 Citations (Scopus)

Abstract

To determine whether or not the fall in coronary perfusion pressure after coronary occlusion is the cause of remote myocardial ischaemia, regional myocardial blood flow was measured using radiolabelled microspheres before and after left anterior descending (LAD) occlusion in the presence of a left circumflex artery stenosis in 22 anaesthetised dogs. Aortic pressure was maintained constant at the time of left anterior descending artery occlusion in 13 dogs (group 1) and proximal left circumflex artery pressure was held constant by a servocontrolled pump in nine dogs with a carotid artery-left circumflex artery shunt (group 2). Despite the maintenance of constant mean aortic pressure in group 1, remote posterior bed mean(SEM) endocardial flow fell from 0.69(0.05) to 0.43(0.07) ml·min-1·g-1 (p<0.05). In the dogs in which left atrial pressure rose to ≤9 mmHg after left anterior descending artery occlusion, remote bed endocardial flow did not fall significantly (0.66(0.07) to 0.56(0.11) ml·min-1·g-1; NS). In contrast, remote bed endocardial flow fell from 0.73(0.07) to 0.28(0.06) ml·min-1·g-1 (p<0.0001) after left anterior descending artery occlusion in the dogs in which left atrial pressure rose to >9 mmHg. The fall in remote bed endocardial flow was prevented in group 2 dogs by maintaining proximal left circumflex artery pressure constant (0.95(0.08) to 0.86(0.09) ml·min-1·g-1; NS).An important mechanism for the development of remote myocardial ischaemia appears to be the fall in proximal coronary perfusion pressure at the time of coronary occlusion.

Original languageEnglish (US)
Pages (from-to)398-406
Number of pages9
JournalCardiovascular Research
Volume22
Issue number6
DOIs
StatePublished - Jan 1 1988

Fingerprint

Coronary Occlusion
Myocardial Ischemia
Thorax
Arteries
Dogs
Pressure
Arterial Pressure
Perfusion
Regional Blood Flow
Microspheres
Carotid Arteries
Pathologic Constriction
Maintenance

All Science Journal Classification (ASJC) codes

  • Physiology
  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

Cite this

Gascho, Joseph ; Flanagan, Terry L. ; Jennings, C. Foster ; Beller, George A. / Mechanism of remote myocardial ischaemia after coronary occlusion in open chest dogs. In: Cardiovascular Research. 1988 ; Vol. 22, No. 6. pp. 398-406.
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abstract = "To determine whether or not the fall in coronary perfusion pressure after coronary occlusion is the cause of remote myocardial ischaemia, regional myocardial blood flow was measured using radiolabelled microspheres before and after left anterior descending (LAD) occlusion in the presence of a left circumflex artery stenosis in 22 anaesthetised dogs. Aortic pressure was maintained constant at the time of left anterior descending artery occlusion in 13 dogs (group 1) and proximal left circumflex artery pressure was held constant by a servocontrolled pump in nine dogs with a carotid artery-left circumflex artery shunt (group 2). Despite the maintenance of constant mean aortic pressure in group 1, remote posterior bed mean(SEM) endocardial flow fell from 0.69(0.05) to 0.43(0.07) ml·min-1·g-1 (p<0.05). In the dogs in which left atrial pressure rose to ≤9 mmHg after left anterior descending artery occlusion, remote bed endocardial flow did not fall significantly (0.66(0.07) to 0.56(0.11) ml·min-1·g-1; NS). In contrast, remote bed endocardial flow fell from 0.73(0.07) to 0.28(0.06) ml·min-1·g-1 (p<0.0001) after left anterior descending artery occlusion in the dogs in which left atrial pressure rose to >9 mmHg. The fall in remote bed endocardial flow was prevented in group 2 dogs by maintaining proximal left circumflex artery pressure constant (0.95(0.08) to 0.86(0.09) ml·min-1·g-1; NS).An important mechanism for the development of remote myocardial ischaemia appears to be the fall in proximal coronary perfusion pressure at the time of coronary occlusion.",
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Mechanism of remote myocardial ischaemia after coronary occlusion in open chest dogs. / Gascho, Joseph; Flanagan, Terry L.; Jennings, C. Foster; Beller, George A.

In: Cardiovascular Research, Vol. 22, No. 6, 01.01.1988, p. 398-406.

Research output: Contribution to journalReview article

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AU - Gascho, Joseph

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N2 - To determine whether or not the fall in coronary perfusion pressure after coronary occlusion is the cause of remote myocardial ischaemia, regional myocardial blood flow was measured using radiolabelled microspheres before and after left anterior descending (LAD) occlusion in the presence of a left circumflex artery stenosis in 22 anaesthetised dogs. Aortic pressure was maintained constant at the time of left anterior descending artery occlusion in 13 dogs (group 1) and proximal left circumflex artery pressure was held constant by a servocontrolled pump in nine dogs with a carotid artery-left circumflex artery shunt (group 2). Despite the maintenance of constant mean aortic pressure in group 1, remote posterior bed mean(SEM) endocardial flow fell from 0.69(0.05) to 0.43(0.07) ml·min-1·g-1 (p<0.05). In the dogs in which left atrial pressure rose to ≤9 mmHg after left anterior descending artery occlusion, remote bed endocardial flow did not fall significantly (0.66(0.07) to 0.56(0.11) ml·min-1·g-1; NS). In contrast, remote bed endocardial flow fell from 0.73(0.07) to 0.28(0.06) ml·min-1·g-1 (p<0.0001) after left anterior descending artery occlusion in the dogs in which left atrial pressure rose to >9 mmHg. The fall in remote bed endocardial flow was prevented in group 2 dogs by maintaining proximal left circumflex artery pressure constant (0.95(0.08) to 0.86(0.09) ml·min-1·g-1; NS).An important mechanism for the development of remote myocardial ischaemia appears to be the fall in proximal coronary perfusion pressure at the time of coronary occlusion.

AB - To determine whether or not the fall in coronary perfusion pressure after coronary occlusion is the cause of remote myocardial ischaemia, regional myocardial blood flow was measured using radiolabelled microspheres before and after left anterior descending (LAD) occlusion in the presence of a left circumflex artery stenosis in 22 anaesthetised dogs. Aortic pressure was maintained constant at the time of left anterior descending artery occlusion in 13 dogs (group 1) and proximal left circumflex artery pressure was held constant by a servocontrolled pump in nine dogs with a carotid artery-left circumflex artery shunt (group 2). Despite the maintenance of constant mean aortic pressure in group 1, remote posterior bed mean(SEM) endocardial flow fell from 0.69(0.05) to 0.43(0.07) ml·min-1·g-1 (p<0.05). In the dogs in which left atrial pressure rose to ≤9 mmHg after left anterior descending artery occlusion, remote bed endocardial flow did not fall significantly (0.66(0.07) to 0.56(0.11) ml·min-1·g-1; NS). In contrast, remote bed endocardial flow fell from 0.73(0.07) to 0.28(0.06) ml·min-1·g-1 (p<0.0001) after left anterior descending artery occlusion in the dogs in which left atrial pressure rose to >9 mmHg. The fall in remote bed endocardial flow was prevented in group 2 dogs by maintaining proximal left circumflex artery pressure constant (0.95(0.08) to 0.86(0.09) ml·min-1·g-1; NS).An important mechanism for the development of remote myocardial ischaemia appears to be the fall in proximal coronary perfusion pressure at the time of coronary occlusion.

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