Mechanisms and context underlying the role of autophagy in cancer metastasis

Christopher M. Dower, Carson A. Wills, Steven M. Frisch, Hong Gang Wang

Research output: Contribution to journalReview article

13 Citations (Scopus)

Abstract

Macroautophagy/autophagy is a fundamental cellular degradation mechanism that maintains cell homeostasis, regulates cell signaling, and promotes cell survival. Its role in promoting tumor cell survival in stress conditions is well characterized, and makes autophagy an attractive target for cancer therapy. Emerging research indicates that autophagy also influences cancer metastasis, which is the primary cause of cancer-associated mortality. However, data demonstrate that the regulatory role of autophagy in metastasis is multifaceted, and includes both metastasis-suppressing and -promoting functions. The metastasis-suppressing functions of autophagy, in particular, have important implications for autophagy-based treatments, as inhibition of autophagy may increase the risk of metastasis. In this review, we discuss the mechanisms and context underlying the role of autophagy in metastasis, which include autophagy-mediated regulation of focal adhesion dynamics, integrin signaling and trafficking, Rho GTPase-mediated cytoskeleton remodeling, anoikis resistance, extracellular matrix remodeling, epithelial-to-mesenchymal transition signaling, and tumor-stromal cell interactions. Through this, we aim to clarify the context-dependent nature of autophagy-mediated metastasis and provide direction for further research investigating the role of autophagy in cancer metastasis.

Original languageEnglish (US)
Pages (from-to)1110-1128
Number of pages19
JournalAutophagy
Volume14
Issue number7
DOIs
StatePublished - Jul 3 2018

Fingerprint

Autophagy
Neoplasm Metastasis
Neoplasms
Cell Survival
Anoikis
rho GTP-Binding Proteins
Focal Adhesions
Epithelial-Mesenchymal Transition
Stromal Cells
Cytoskeleton
Research
Integrins
Cell Communication
Extracellular Matrix
Homeostasis

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Cell Biology

Cite this

Dower, Christopher M. ; Wills, Carson A. ; Frisch, Steven M. ; Wang, Hong Gang. / Mechanisms and context underlying the role of autophagy in cancer metastasis. In: Autophagy. 2018 ; Vol. 14, No. 7. pp. 1110-1128.
@article{4c4a6f0ed3f3446ea8afc0f4bd98c2e3,
title = "Mechanisms and context underlying the role of autophagy in cancer metastasis",
abstract = "Macroautophagy/autophagy is a fundamental cellular degradation mechanism that maintains cell homeostasis, regulates cell signaling, and promotes cell survival. Its role in promoting tumor cell survival in stress conditions is well characterized, and makes autophagy an attractive target for cancer therapy. Emerging research indicates that autophagy also influences cancer metastasis, which is the primary cause of cancer-associated mortality. However, data demonstrate that the regulatory role of autophagy in metastasis is multifaceted, and includes both metastasis-suppressing and -promoting functions. The metastasis-suppressing functions of autophagy, in particular, have important implications for autophagy-based treatments, as inhibition of autophagy may increase the risk of metastasis. In this review, we discuss the mechanisms and context underlying the role of autophagy in metastasis, which include autophagy-mediated regulation of focal adhesion dynamics, integrin signaling and trafficking, Rho GTPase-mediated cytoskeleton remodeling, anoikis resistance, extracellular matrix remodeling, epithelial-to-mesenchymal transition signaling, and tumor-stromal cell interactions. Through this, we aim to clarify the context-dependent nature of autophagy-mediated metastasis and provide direction for further research investigating the role of autophagy in cancer metastasis.",
author = "Dower, {Christopher M.} and Wills, {Carson A.} and Frisch, {Steven M.} and Wang, {Hong Gang}",
year = "2018",
month = "7",
day = "3",
doi = "10.1080/15548627.2018.1450020",
language = "English (US)",
volume = "14",
pages = "1110--1128",
journal = "Autophagy",
issn = "1554-8627",
publisher = "Landes Bioscience",
number = "7",

}

Mechanisms and context underlying the role of autophagy in cancer metastasis. / Dower, Christopher M.; Wills, Carson A.; Frisch, Steven M.; Wang, Hong Gang.

In: Autophagy, Vol. 14, No. 7, 03.07.2018, p. 1110-1128.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Mechanisms and context underlying the role of autophagy in cancer metastasis

AU - Dower, Christopher M.

AU - Wills, Carson A.

AU - Frisch, Steven M.

AU - Wang, Hong Gang

PY - 2018/7/3

Y1 - 2018/7/3

N2 - Macroautophagy/autophagy is a fundamental cellular degradation mechanism that maintains cell homeostasis, regulates cell signaling, and promotes cell survival. Its role in promoting tumor cell survival in stress conditions is well characterized, and makes autophagy an attractive target for cancer therapy. Emerging research indicates that autophagy also influences cancer metastasis, which is the primary cause of cancer-associated mortality. However, data demonstrate that the regulatory role of autophagy in metastasis is multifaceted, and includes both metastasis-suppressing and -promoting functions. The metastasis-suppressing functions of autophagy, in particular, have important implications for autophagy-based treatments, as inhibition of autophagy may increase the risk of metastasis. In this review, we discuss the mechanisms and context underlying the role of autophagy in metastasis, which include autophagy-mediated regulation of focal adhesion dynamics, integrin signaling and trafficking, Rho GTPase-mediated cytoskeleton remodeling, anoikis resistance, extracellular matrix remodeling, epithelial-to-mesenchymal transition signaling, and tumor-stromal cell interactions. Through this, we aim to clarify the context-dependent nature of autophagy-mediated metastasis and provide direction for further research investigating the role of autophagy in cancer metastasis.

AB - Macroautophagy/autophagy is a fundamental cellular degradation mechanism that maintains cell homeostasis, regulates cell signaling, and promotes cell survival. Its role in promoting tumor cell survival in stress conditions is well characterized, and makes autophagy an attractive target for cancer therapy. Emerging research indicates that autophagy also influences cancer metastasis, which is the primary cause of cancer-associated mortality. However, data demonstrate that the regulatory role of autophagy in metastasis is multifaceted, and includes both metastasis-suppressing and -promoting functions. The metastasis-suppressing functions of autophagy, in particular, have important implications for autophagy-based treatments, as inhibition of autophagy may increase the risk of metastasis. In this review, we discuss the mechanisms and context underlying the role of autophagy in metastasis, which include autophagy-mediated regulation of focal adhesion dynamics, integrin signaling and trafficking, Rho GTPase-mediated cytoskeleton remodeling, anoikis resistance, extracellular matrix remodeling, epithelial-to-mesenchymal transition signaling, and tumor-stromal cell interactions. Through this, we aim to clarify the context-dependent nature of autophagy-mediated metastasis and provide direction for further research investigating the role of autophagy in cancer metastasis.

UR - http://www.scopus.com/inward/record.url?scp=85052222002&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85052222002&partnerID=8YFLogxK

U2 - 10.1080/15548627.2018.1450020

DO - 10.1080/15548627.2018.1450020

M3 - Review article

C2 - 29863947

AN - SCOPUS:85052222002

VL - 14

SP - 1110

EP - 1128

JO - Autophagy

JF - Autophagy

SN - 1554-8627

IS - 7

ER -