TY - JOUR
T1 - Mechanisms of bacterial tolerance and persistence in the gastrointestinal and respiratory environments
AU - Trastoy, R.
AU - Manso, T.
AU - Fernández-García, L.
AU - Blasco, L.
AU - Ambroa, A.
AU - Pérez Del Molino, M. L.
AU - Bou, G.
AU - García-Contreras, R.
AU - Wood, T. K.
AU - Tomás, M.
N1 - Funding Information:
This study was funded by grants PI13/02390 and PI16/01163, awarded to M. Tomás within the State Plan for R+D+I 2013–2016 (National Plan for Scientific Research, Technological Development and Innovation 2008–2011) and cofinanced by the ISCIII-Deputy General Directorate of Evaluation and Promotion of Research-European Regional Development Fund “A Way of Making Europe” and the Instituto de Salud Carlos III FEDER, Spanish Network for Research in Infectious Diseases (REIPI) (grants RD16/ 0016/0001 and RD16/0016/0006), as well as the Study Group on Mechanisms of Action and Resistance to Antimicrobials (GEMARA; SEIMC). M. Tomás was financially supported by the Miguel Servet Research Programme (SERGAS and ISCIII). R. Trastoy and L. Fernández-García were financially supported by a postspeciality from the Fundación Novo Santos (CHUAC-SERGAS, Galicia, Spain) and a predoctoral fellowship from the Xunta de Galicia (GAIN, Axencia de Innovación), respectively.
Funding Information:
This study was funded by grants PI13/02390 and PI16/01163, awarded to M. Tomás within the State Plan for R+D+I 2013–2016 (National Plan for Scientific Research, Technological Development and Innovation 2008 –2011) and cofinanced by the ISCIII-Deputy General Directorate of Evaluation and Promotion of Research-European Regional Development Fund “A Way of Making Europe” and the Instituto de Salud Carlos III FEDER, Spanish Network for Research in Infectious Diseases (REIPI) (grants RD16/ 0016/0001 and RD16/0016/0006), as well as the Study Group on Mechanisms of Action and Resistance to Antimicrobials (GEMARA; SEIMC). M. Tomás was financially supported by the Miguel Servet Research Programme (SERGAS and ISCIII). R. Trastoy and L. Fernández-García were financially supported by a postspeciality from the Fundación
Publisher Copyright:
© 2018, American Society for Microbiology. All rights reserved.
PY - 2018/10
Y1 - 2018/10
N2 - Pathogens that infect the gastrointestinal and respiratory tracts are subjected to intense pressure due to the environmental conditions of the surroundings. This pressure has led to the development of mechanisms of bacterial tolerance or persistence which enable microorganisms to survive in these locations. In this review, we analyze the general stress response (RpoS mediated), reactive oxygen species (ROS) tolerance, energy metabolism, drug efflux pumps, SOS response, quorum sensing (QS) bacterial communication, (p)ppGpp signaling, and toxin-antitoxin (TA) systems of pathogens, such as Escherichia coli, Salmonella spp., Vibrio spp., Helicobacter spp., Campylobacter jejuni, Enterococcus spp., Shigella spp., Yersinia spp., and Clostridium difficile, all of which inhabit the gastrointestinal tract. The following respiratory tract pathogens are also considered: Staphylococcus aureus, Pseudomonas aeruginosa, Acinetobacter baumannii, Burkholderia cenocepacia, and Mycobacterium tuberculosis. Knowledge of the molecular mechanisms regulating the bacterial tolerance and persistence phenotypes is essential in the fight against multiresistant pathogens, as it will enable the identification of new targets for developing innovative anti-infective treatments.
AB - Pathogens that infect the gastrointestinal and respiratory tracts are subjected to intense pressure due to the environmental conditions of the surroundings. This pressure has led to the development of mechanisms of bacterial tolerance or persistence which enable microorganisms to survive in these locations. In this review, we analyze the general stress response (RpoS mediated), reactive oxygen species (ROS) tolerance, energy metabolism, drug efflux pumps, SOS response, quorum sensing (QS) bacterial communication, (p)ppGpp signaling, and toxin-antitoxin (TA) systems of pathogens, such as Escherichia coli, Salmonella spp., Vibrio spp., Helicobacter spp., Campylobacter jejuni, Enterococcus spp., Shigella spp., Yersinia spp., and Clostridium difficile, all of which inhabit the gastrointestinal tract. The following respiratory tract pathogens are also considered: Staphylococcus aureus, Pseudomonas aeruginosa, Acinetobacter baumannii, Burkholderia cenocepacia, and Mycobacterium tuberculosis. Knowledge of the molecular mechanisms regulating the bacterial tolerance and persistence phenotypes is essential in the fight against multiresistant pathogens, as it will enable the identification of new targets for developing innovative anti-infective treatments.
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U2 - 10.1128/CMR.00023-18
DO - 10.1128/CMR.00023-18
M3 - Review article
C2 - 30068737
AN - SCOPUS:85052052742
VL - 31
JO - Clinical Microbiology Reviews
JF - Clinical Microbiology Reviews
SN - 0893-8512
IS - 4
M1 - e00023-18
ER -
