Mechanisms of communication between mitochondria and lysosomes

Nuno Raimundo, Lorena Fernández-Mosquera, King Faisal Yambire, Cátia V. Diogo

Research output: Contribution to journalShort surveypeer-review

21 Scopus citations

Abstract

Mitochondria and lysosomes have long been studied in the context of their classic functions: energy factory and recycle bin, respectively. In the last twenty years, it became evident that these organelles are much more than simple industrial units, and are indeed in charge of many of cellular processes. Both mitochondria and lysosomes are now recognized as far-reaching signaling platforms, regulating many key aspects of cell and tissue physiology. It has furthermore become clear that mitochondria and lysosomes impact each other. The mechanisms underlying the cross-talk between these organelles are only now starting to be addressed. In this review, we briefly summarize how mitochondria, lysosomes and the lysosome-related process of autophagy affect each other in physiology and pathology.

Original languageEnglish (US)
Pages (from-to)345-349
Number of pages5
JournalInternational Journal of Biochemistry and Cell Biology
Volume79
DOIs
StatePublished - Oct 1 2016

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Cell Biology

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