TY - JOUR
T1 - Mechanisms of communication between mitochondria and lysosomes
AU - Raimundo, Nuno
AU - Fernández-Mosquera, Lorena
AU - Yambire, King Faisal
AU - Diogo, Cátia V.
N1 - Funding Information:
NR lab is funded by Starting Grant 337327 by the European Research Council and by Deutsche Forschungsgemeinschaft Collaborative Research Center SFB1190. CVD is supported by a fellowship from Peter und Traudl Foundation.
Publisher Copyright:
© 2016 Elsevier Ltd
PY - 2016/10/1
Y1 - 2016/10/1
N2 - Mitochondria and lysosomes have long been studied in the context of their classic functions: energy factory and recycle bin, respectively. In the last twenty years, it became evident that these organelles are much more than simple industrial units, and are indeed in charge of many of cellular processes. Both mitochondria and lysosomes are now recognized as far-reaching signaling platforms, regulating many key aspects of cell and tissue physiology. It has furthermore become clear that mitochondria and lysosomes impact each other. The mechanisms underlying the cross-talk between these organelles are only now starting to be addressed. In this review, we briefly summarize how mitochondria, lysosomes and the lysosome-related process of autophagy affect each other in physiology and pathology.
AB - Mitochondria and lysosomes have long been studied in the context of their classic functions: energy factory and recycle bin, respectively. In the last twenty years, it became evident that these organelles are much more than simple industrial units, and are indeed in charge of many of cellular processes. Both mitochondria and lysosomes are now recognized as far-reaching signaling platforms, regulating many key aspects of cell and tissue physiology. It has furthermore become clear that mitochondria and lysosomes impact each other. The mechanisms underlying the cross-talk between these organelles are only now starting to be addressed. In this review, we briefly summarize how mitochondria, lysosomes and the lysosome-related process of autophagy affect each other in physiology and pathology.
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U2 - 10.1016/j.biocel.2016.08.020
DO - 10.1016/j.biocel.2016.08.020
M3 - Short survey
C2 - 27613573
AN - SCOPUS:84986274061
VL - 79
SP - 345
EP - 349
JO - International Journal of Biochemistry
JF - International Journal of Biochemistry
SN - 1357-2725
ER -