Mechanisms of Erythropoietin Signal Transduction: Involvement of Calcium Channels

Barbara A. Miller, Joseph Y. Cheung

Research output: Contribution to journalArticlepeer-review

31 Scopus citations

Abstract

Erythropoietin (Epo) induces a dose-dependent increase in intracellular free calcium concentration ([Ca1]) in single human BFU-E derived erythroblasts, which is specific for stage of differentiation and mediated through a voltage-independent ion channel permeable to calcium. This minireview examines the regulation of calcium channels by Epo during normal erythroid differentiation, as a model to delineate the immediate signaling events which follow interaction of Epo with its receptor.

Original languageEnglish (US)
Pages (from-to)263-267
Number of pages5
JournalProceedings of the Society for Experimental Biology and Medicine
Volume206
Issue number3
DOIs
StatePublished - Jul 1994

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

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