Mechanisms of Erythropoietin Signal Transduction: Involvement of Calcium Channels

Barbara A. Miller, Joseph Y. Cheung

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Erythropoietin (Epo) induces a dose-dependent increase in intracellular free calcium concentration ([Ca1]) in single human BFU-E derived erythroblasts, which is specific for stage of differentiation and mediated through a voltage-independent ion channel permeable to calcium. This minireview examines the regulation of calcium channels by Epo during normal erythroid differentiation, as a model to delineate the immediate signaling events which follow interaction of Epo with its receptor.

Original languageEnglish (US)
Pages (from-to)263-267
Number of pages5
JournalProceedings of the Society for Experimental Biology and Medicine
Volume206
Issue number3
DOIs
StatePublished - Jul 1994

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Signal transduction
Calcium Channels
Erythropoietin
Signal Transduction
Calcium
Erythroblasts
Erythroid Precursor Cells
Ion Channels
Electric potential

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

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Mechanisms of Erythropoietin Signal Transduction : Involvement of Calcium Channels. / Miller, Barbara A.; Cheung, Joseph Y.

In: Proceedings of the Society for Experimental Biology and Medicine, Vol. 206, No. 3, 07.1994, p. 263-267.

Research output: Contribution to journalArticle

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