Erythropoietin (Epo) induces a dose-dependent increase in intracellular free calcium concentration ([Ca1]) in single human BFU-E derived erythroblasts, which is specific for stage of differentiation and mediated through a voltage-independent ion channel permeable to calcium. This minireview examines the regulation of calcium channels by Epo during normal erythroid differentiation, as a model to delineate the immediate signaling events which follow interaction of Epo with its receptor.
|Original language||English (US)|
|Number of pages||5|
|Journal||Proceedings of the Society for Experimental Biology and Medicine|
|State||Published - Jul 1994|
All Science Journal Classification (ASJC) codes
- Biochemistry, Genetics and Molecular Biology(all)