Mechanisms of phospholipase C-regulated calcium entry

Gary S. Bird, Omar Aziz, Jean Philippe Lievremont, Barbara J. Wedel, Mohamed Trebak, Guillermo Vazquez, James W. Putney

Research output: Contribution to journalReview article

74 Citations (Scopus)

Abstract

In a variety of cell types, activation of phospholipase C-linked receptors results in the generation of intracellular Ca2+ signals comprised of components of both intracellular Ca2+ release, and enhanced entry of Ca2+ across the plasma membrane. This entry of Ca2+ occurs by either of two general mechanisms: the release of stored Ca2+ can activate, by an unknown mechanism, store-operated channels in the plasma membrane, a process known as capacitative calcium entry. Alternatively, second messengers generated at the plasma membrane can activate Ca2+ channels more directly, a non-capacitative calcium entry process. This review summarizes current knowledge of the underlying signaling mechanisms and the nature of the channel molecules responsible for these two general categories of regulated Ca2+ entry.

Original languageEnglish (US)
Pages (from-to)291-301
Number of pages11
JournalCurrent Molecular Medicine
Volume4
Issue number3
DOIs
StatePublished - May 1 2004

Fingerprint

Type C Phospholipases
Cell membranes
Cell Membrane
Calcium
Second Messenger Systems
Chemical activation
Molecules

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology

Cite this

Bird, G. S., Aziz, O., Lievremont, J. P., Wedel, B. J., Trebak, M., Vazquez, G., & Putney, J. W. (2004). Mechanisms of phospholipase C-regulated calcium entry. Current Molecular Medicine, 4(3), 291-301. https://doi.org/10.2174/1566524043360681
Bird, Gary S. ; Aziz, Omar ; Lievremont, Jean Philippe ; Wedel, Barbara J. ; Trebak, Mohamed ; Vazquez, Guillermo ; Putney, James W. / Mechanisms of phospholipase C-regulated calcium entry. In: Current Molecular Medicine. 2004 ; Vol. 4, No. 3. pp. 291-301.
@article{ccec3c6fde0c41bdb6ee81362aa2ecc5,
title = "Mechanisms of phospholipase C-regulated calcium entry",
abstract = "In a variety of cell types, activation of phospholipase C-linked receptors results in the generation of intracellular Ca2+ signals comprised of components of both intracellular Ca2+ release, and enhanced entry of Ca2+ across the plasma membrane. This entry of Ca2+ occurs by either of two general mechanisms: the release of stored Ca2+ can activate, by an unknown mechanism, store-operated channels in the plasma membrane, a process known as capacitative calcium entry. Alternatively, second messengers generated at the plasma membrane can activate Ca2+ channels more directly, a non-capacitative calcium entry process. This review summarizes current knowledge of the underlying signaling mechanisms and the nature of the channel molecules responsible for these two general categories of regulated Ca2+ entry.",
author = "Bird, {Gary S.} and Omar Aziz and Lievremont, {Jean Philippe} and Wedel, {Barbara J.} and Mohamed Trebak and Guillermo Vazquez and Putney, {James W.}",
year = "2004",
month = "5",
day = "1",
doi = "10.2174/1566524043360681",
language = "English (US)",
volume = "4",
pages = "291--301",
journal = "Current Molecular Medicine",
issn = "1566-5240",
publisher = "Bentham Science Publishers B.V.",
number = "3",

}

Bird, GS, Aziz, O, Lievremont, JP, Wedel, BJ, Trebak, M, Vazquez, G & Putney, JW 2004, 'Mechanisms of phospholipase C-regulated calcium entry', Current Molecular Medicine, vol. 4, no. 3, pp. 291-301. https://doi.org/10.2174/1566524043360681

Mechanisms of phospholipase C-regulated calcium entry. / Bird, Gary S.; Aziz, Omar; Lievremont, Jean Philippe; Wedel, Barbara J.; Trebak, Mohamed; Vazquez, Guillermo; Putney, James W.

In: Current Molecular Medicine, Vol. 4, No. 3, 01.05.2004, p. 291-301.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Mechanisms of phospholipase C-regulated calcium entry

AU - Bird, Gary S.

AU - Aziz, Omar

AU - Lievremont, Jean Philippe

AU - Wedel, Barbara J.

AU - Trebak, Mohamed

AU - Vazquez, Guillermo

AU - Putney, James W.

PY - 2004/5/1

Y1 - 2004/5/1

N2 - In a variety of cell types, activation of phospholipase C-linked receptors results in the generation of intracellular Ca2+ signals comprised of components of both intracellular Ca2+ release, and enhanced entry of Ca2+ across the plasma membrane. This entry of Ca2+ occurs by either of two general mechanisms: the release of stored Ca2+ can activate, by an unknown mechanism, store-operated channels in the plasma membrane, a process known as capacitative calcium entry. Alternatively, second messengers generated at the plasma membrane can activate Ca2+ channels more directly, a non-capacitative calcium entry process. This review summarizes current knowledge of the underlying signaling mechanisms and the nature of the channel molecules responsible for these two general categories of regulated Ca2+ entry.

AB - In a variety of cell types, activation of phospholipase C-linked receptors results in the generation of intracellular Ca2+ signals comprised of components of both intracellular Ca2+ release, and enhanced entry of Ca2+ across the plasma membrane. This entry of Ca2+ occurs by either of two general mechanisms: the release of stored Ca2+ can activate, by an unknown mechanism, store-operated channels in the plasma membrane, a process known as capacitative calcium entry. Alternatively, second messengers generated at the plasma membrane can activate Ca2+ channels more directly, a non-capacitative calcium entry process. This review summarizes current knowledge of the underlying signaling mechanisms and the nature of the channel molecules responsible for these two general categories of regulated Ca2+ entry.

UR - http://www.scopus.com/inward/record.url?scp=1942517491&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=1942517491&partnerID=8YFLogxK

U2 - 10.2174/1566524043360681

DO - 10.2174/1566524043360681

M3 - Review article

C2 - 15101686

AN - SCOPUS:1942517491

VL - 4

SP - 291

EP - 301

JO - Current Molecular Medicine

JF - Current Molecular Medicine

SN - 1566-5240

IS - 3

ER -

Bird GS, Aziz O, Lievremont JP, Wedel BJ, Trebak M, Vazquez G et al. Mechanisms of phospholipase C-regulated calcium entry. Current Molecular Medicine. 2004 May 1;4(3):291-301. https://doi.org/10.2174/1566524043360681