Mechanisms of suberoylanilide hydroxamic acid inhibition of mammary cell growth

T. K. Said, R. C.B. Moraes, R. Sinha, D. Medina

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

The mechanism of suberoylanilide hydroxamic acid in cell growth inhibition involved induction of pRb-2/p130 interaction and nuclear translocation with E2F-4, followed by significant repression in E2F-1 and PCNA nuclear levels, which led to inhibition in DNA synthesis in mammary epithelial cell lines.

Original languageEnglish (US)
Pages (from-to)122-133
Number of pages12
JournalBreast Cancer Research
Volume3
Issue number2
DOIs
StatePublished - Apr 17 2001

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Proliferating Cell Nuclear Antigen
Breast
Epithelial Cells
Cell Line
DNA
Growth
vorinostat

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Said, T. K. ; Moraes, R. C.B. ; Sinha, R. ; Medina, D. / Mechanisms of suberoylanilide hydroxamic acid inhibition of mammary cell growth. In: Breast Cancer Research. 2001 ; Vol. 3, No. 2. pp. 122-133.
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Mechanisms of suberoylanilide hydroxamic acid inhibition of mammary cell growth. / Said, T. K.; Moraes, R. C.B.; Sinha, R.; Medina, D.

In: Breast Cancer Research, Vol. 3, No. 2, 17.04.2001, p. 122-133.

Research output: Contribution to journalArticle

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