Mechanisms of suberoylanilide hydroxamic acid inhibition of mammary cell growth

T. K. Said, R. C.B. Moraes, R. Sinha, D. Medina

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

The mechanism of suberoylanilide hydroxamic acid in cell growth inhibition involved induction of pRb-2/p130 interaction and nuclear translocation with E2F-4, followed by significant repression in E2F-1 and PCNA nuclear levels, which led to inhibition in DNA synthesis in mammary epithelial cell lines.

Original languageEnglish (US)
Pages (from-to)122-133
Number of pages12
JournalBreast Cancer Research
Volume3
Issue number2
DOIs
StatePublished - 2001

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Fingerprint Dive into the research topics of 'Mechanisms of suberoylanilide hydroxamic acid inhibition of mammary cell growth'. Together they form a unique fingerprint.

  • Cite this