Mechanochemical kinetics of transcription elongation

Lu Bai, Robert M. Fulbright, Michelle D. Wang

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Abstract

The mechanochemical kinetics of transcription elongation was examined with a combination of theoretical and experimental approaches. The predictive power of a sequence-dependent thermal ratchet model for transcription elongation was tested by establishing model parameters based solely on measurements under chemical perturbations and then directly predicting responses under mechanical perturbations without additional model parameters. Agreement between predicted and measured force-velocity curves provides strong support for a simple mechanochemical coupling mechanism.

Original languageEnglish (US)
Article number068103
JournalPhysical Review Letters
Volume98
Issue number6
DOIs
StatePublished - Feb 8 2007

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All Science Journal Classification (ASJC) codes

  • Physics and Astronomy(all)

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