TY - JOUR
T1 - Mechanomorphogenic Films Formed via Interfacial Assembly of Fluorinated Amino Acids
AU - Sloand, Janna N.
AU - Culp, Tyler E.
AU - Wonderling, Nichole M.
AU - Gomez, Enrique D.
AU - Medina, Scott H.
N1 - Funding Information:
The authors acknowledge and thank the Penn State Microscopy and Cytometry Facility–University Park, PA for use of circular dichroism instrumentation. The authors also acknowledge the Penn State Materials Characterization Laboratory–University Park, PA for use of the electron microscopy instrumentation and assistance with powder X‐ray diffraction. Funding for this research was provided by the NSF Faculty Early Career Development Program (CAREER) to S.H.M. under award number DMR‐1845053. J.N.S. acknowledges funding support from the Penn State Graduate Research Fellowship. T.E.C. and E.D.G. acknowledge funding support from NSF through DMR‐1905550.
Publisher Copyright:
© 2021 Wiley-VCH GmbH
PY - 2021/10/1
Y1 - 2021/10/1
N2 - Nature has evolved several elegant strategies to organize inert building blocks into adaptive supramolecular structures. Favored among these is interfacial self-assembly, where the unique environment of liquid–liquid junctions provides structural, kinetic, thermodynamic, and chemical properties that are distinct from the bulk solution. Here, antithetical fluorous–water interfaces are exploited to guide the assembly of non-canonical fluorinated amino acids into crystalline mechanomorphogenic films. That is, the nanoscale order imparted by this strategy yields self-healing materials that can alter their macro-morphology depending on exogenous mechanical stimuli. Additionally, like natural biomolecules, organofluorine amino acid films respond to changes in environmental ionic strength, pH, and temperature to adopt varied secondary and tertiary states. Complementary biophysical and biochemical studies are used to develop a model of amino acid packing to rationalize this bioresponsive behavior. Finally, these films show selective permeability, capturing fluorous compounds while allowing the free diffusion of water. These unique capabilities are leveraged in an exemplary application of the technology to extract perfluoroalkyl substances from contaminated water samples rapidly. Continued exploration of these materials will advance the understanding of how interface-templated and fluorine-driven assembly phenomenon a can be co-utilized to design adaptive molecular networks and living matter.
AB - Nature has evolved several elegant strategies to organize inert building blocks into adaptive supramolecular structures. Favored among these is interfacial self-assembly, where the unique environment of liquid–liquid junctions provides structural, kinetic, thermodynamic, and chemical properties that are distinct from the bulk solution. Here, antithetical fluorous–water interfaces are exploited to guide the assembly of non-canonical fluorinated amino acids into crystalline mechanomorphogenic films. That is, the nanoscale order imparted by this strategy yields self-healing materials that can alter their macro-morphology depending on exogenous mechanical stimuli. Additionally, like natural biomolecules, organofluorine amino acid films respond to changes in environmental ionic strength, pH, and temperature to adopt varied secondary and tertiary states. Complementary biophysical and biochemical studies are used to develop a model of amino acid packing to rationalize this bioresponsive behavior. Finally, these films show selective permeability, capturing fluorous compounds while allowing the free diffusion of water. These unique capabilities are leveraged in an exemplary application of the technology to extract perfluoroalkyl substances from contaminated water samples rapidly. Continued exploration of these materials will advance the understanding of how interface-templated and fluorine-driven assembly phenomenon a can be co-utilized to design adaptive molecular networks and living matter.
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U2 - 10.1002/adfm.202104223
DO - 10.1002/adfm.202104223
M3 - Article
AN - SCOPUS:85108323263
VL - 31
JO - Advanced Functional Materials
JF - Advanced Functional Materials
SN - 1616-301X
IS - 40
M1 - 2104223
ER -