Medial prefrontal cortex hyperactivation during social exclusion in borderline personality disorder

Anthony C. Ruocco, John D. Medaglia, Jennifer R. Tinker, Hasan Ayaz, Evan M. Forman, Cory F. Newman, J. Michael Williams, Frank Gerard Hillary, Steven M. Platek, Banu Onaral, Douglas L. Chute

Research output: Contribution to journalArticle

52 Citations (Scopus)

Abstract

Frontal systems dysfunction and abandonment fears represent central features of borderline personality disorder (BPD). BPD subjects (n = 10) and matched non-psychiatric comparison subjects (n = 10) completed a social-cognitive task with two confederates instructed to either include or exclude subjects from a circumscribed interaction. Evoked cerebral blood oxygenation in frontal cortex was measured using 16-channel functional near infrared spectroscopy. BPD subjects showed left medial prefrontal cortex hyperactivation during social exclusion suggesting potential dysfunction of frontolimbic circuitry.

Original languageEnglish (US)
Pages (from-to)233-236
Number of pages4
JournalPsychiatry Research - Neuroimaging
Volume181
Issue number3
DOIs
StatePublished - Mar 30 2010

Fingerprint

Borderline Personality Disorder
Prefrontal Cortex
Near-Infrared Spectroscopy
Frontal Lobe
Fear

All Science Journal Classification (ASJC) codes

  • Neuroscience (miscellaneous)
  • Radiology Nuclear Medicine and imaging
  • Psychiatry and Mental health

Cite this

Ruocco, A. C., Medaglia, J. D., Tinker, J. R., Ayaz, H., Forman, E. M., Newman, C. F., ... Chute, D. L. (2010). Medial prefrontal cortex hyperactivation during social exclusion in borderline personality disorder. Psychiatry Research - Neuroimaging, 181(3), 233-236. https://doi.org/10.1016/j.pscychresns.2009.12.001
Ruocco, Anthony C. ; Medaglia, John D. ; Tinker, Jennifer R. ; Ayaz, Hasan ; Forman, Evan M. ; Newman, Cory F. ; Williams, J. Michael ; Hillary, Frank Gerard ; Platek, Steven M. ; Onaral, Banu ; Chute, Douglas L. / Medial prefrontal cortex hyperactivation during social exclusion in borderline personality disorder. In: Psychiatry Research - Neuroimaging. 2010 ; Vol. 181, No. 3. pp. 233-236.
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Ruocco, AC, Medaglia, JD, Tinker, JR, Ayaz, H, Forman, EM, Newman, CF, Williams, JM, Hillary, FG, Platek, SM, Onaral, B & Chute, DL 2010, 'Medial prefrontal cortex hyperactivation during social exclusion in borderline personality disorder', Psychiatry Research - Neuroimaging, vol. 181, no. 3, pp. 233-236. https://doi.org/10.1016/j.pscychresns.2009.12.001

Medial prefrontal cortex hyperactivation during social exclusion in borderline personality disorder. / Ruocco, Anthony C.; Medaglia, John D.; Tinker, Jennifer R.; Ayaz, Hasan; Forman, Evan M.; Newman, Cory F.; Williams, J. Michael; Hillary, Frank Gerard; Platek, Steven M.; Onaral, Banu; Chute, Douglas L.

In: Psychiatry Research - Neuroimaging, Vol. 181, No. 3, 30.03.2010, p. 233-236.

Research output: Contribution to journalArticle

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