Medicinal potential of the root of Arctotis arctotoides

A. J. Afolayan, F. O. Jimoh, M. O. Sofidiya, Srinivas Koduru, F. B. Lewu

Research output: Contribution to journalArticlepeer-review

20 Scopus citations

Abstract

The antioxidant and antimicrobial activity of the acetone, methanol, and water extracts from the root of Arctotis arctotoides (L.f.) O. Hoffm (Asteraceae) were assessed in an effort to validate the medicinal potential of the subterranean part of the herb. The antioxidant activities of acetone and methanol extracts as determined by the ABTS, DPPH, and FRAP methods were higher than that of water extracts. The extracts showed significant activity against both Gram-positive and Gram-negative bacteria. The strongest activity was found in the acetone extract on Bacillus cereus, Staphylococcus aureus, Micrococcus kristinae, and Streptococcus pyrogens with an MIC of 0.1 mg/mL. Although not completely fungicidal, these extracts showed significant growth inhibition against all the fungi tested. Antioxidant and antimicrobial activities of the extracts were strongly correlated with total phenols and to a lesser extent with their flavonoids and proanthocyanidins contents. This study has validated the medicinal potential of the underground part of A. arctotoides.

Original languageEnglish (US)
Pages (from-to)486-493
Number of pages8
JournalPharmaceutical Biology
Volume45
Issue number6
DOIs
StatePublished - Jul 1 2007

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine

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