MEF-2 isoforms' (A-D) roles in development and tumorigenesis

Kiran Madugula, Ria Mulherkar, Zafar K. Khan, De Gaulle I. Chigbu, Dip Patel, Edward W. Harhaj, Pooja Jain

Research output: Contribution to journalReview article

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Abstract

Myocyte enhancer factor (MEF)-2 plays a critical role in proliferation, differentiation, and development of various cell types in a tissue specific manner. Four isoforms of MEF-2 (A-D) differentially participate in controlling the cell fate during the developmental phases of cardiac, muscle, vascular, immune and skeletal systems. Through their associations with various cellular factors MEF-2 isoforms can trigger alterations in complex protein networks and modulate various stages of cellular differentiation, proliferation, survival and apoptosis. The role of the MEF-2 family of transcription factors in the development has been investigated in various cell types, and the evolving alterations in this family of transcription factors have resulted in a diverse and wide spectrum of disease phenotypes, ranging from cancer to infection. This review provides a comprehensive account on MEF-2 isoforms (A-D) from their respective localization, signaling, role in development and tumorigenesis as well as their association with histone deacetylases (HDACs), which can be exploited for therapeutic intervention.

Original languageEnglish (US)
Pages (from-to)2755-2787
Number of pages33
JournalOncotarget
Volume10
Issue number28
DOIs
StatePublished - Apr 12 2019

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All Science Journal Classification (ASJC) codes

  • Oncology

Cite this

Madugula, K., Mulherkar, R., Khan, Z. K., Chigbu, D. G. I., Patel, D., Harhaj, E. W., & Jain, P. (2019). MEF-2 isoforms' (A-D) roles in development and tumorigenesis. Oncotarget, 10(28), 2755-2787. https://doi.org/10.18632/oncotarget.26763