Melatonin secretion after surgery

Arthur J. Cronin, John C. Keifer, Matthew F. Davies, Tonya S. King, Edward O. Bixler

Research output: Contribution to journalArticle

75 Scopus citations


Sleep disturbance is common postoperatively. We examined whether melatonin concentrations were related to this disturbance in seven postoperative patients. Nocturnal concentrations of melatonin were significantly (p=0.005) lower on the first than on the second or third nights after surgery. This finding raises the possibility that melatonin suppression and associated sleep disturbance might be prevented by melatonin replacement.

Original languageEnglish (US)
Pages (from-to)1244-1245
Number of pages2
Issue number9237
Publication statusPublished - Oct 7 2000


All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Cronin, A. J., Keifer, J. C., Davies, M. F., King, T. S., & Bixler, E. O. (2000). Melatonin secretion after surgery. Lancet, 356(9237), 1244-1245.