Members of the Fusarium solani species complex that cause infections in both humans and plants are common in the environment

Ning Zhang, Kerry O'Donnell, Deanna A. Sutton, F. Ameena Nalim, Richard C. Summerbell, Arvind A. Padhye, David M. Geiser

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Abstract

Members of the Fusarium solani species complex (FSSC) are increasingly implicated as the causative agents of human mycoses, particularly in the expanding immunocompromised and immunosuppressed patient populations. Best known as ubiquitous plant pathogens and saprotrophs, the FSSC comprises over 45 phylogenetically distinct species distributed among three major clades. To identify which species are associated with human infections, we generated multilocus haplotypes based on four partial gene sequences from 471 isolates. Of these, 278 were from human patients, 21 were from hospital environments, and 172 were from other sources. Phylogenetic trees inferred from an ergosterol biosynthesis gene (erg-3) were highly discordant with those inferred from the three other partial gene sequences; therefore, this partition was analyzed separately. Multilocus analysis showed that isolates from humans were restricted to but spread throughout clade 3 of the FSSC phylogeny, comprising at least 18 phylogenetically distinct species. The majority (74.5%) of the clinical isolates, however, were associated with four major lineages, designated groups 1 to 4. Groups 1 and 2 were strongly supported as phylogenetic species, whereas groups 3 and 4 were not. Although isolates from ocular infections were found in all four groups, they had a significant tendency to belong to group 3 (P < 0.001). Human clinical isolates shared identical multilocus haplotypes with isolates from plants, other animals, and from hospital environments, suggesting potential nosocomiality. The major finding of this study is that FSSC-associated mycoses of humans and other animals have origins in a broad phylogenetic spectrum, indicating widespread ability to cause infection in this diverse species complex.

Original languageEnglish (US)
Pages (from-to)2185-2190
Number of pages6
JournalJournal of clinical microbiology
Volume44
Issue number6
DOIs
StatePublished - Jun 1 2006

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Fusarium
Infection
Mycoses
Haplotypes
Genes
Animal Hospitals
Eye Infections
Ergosterol
Immunocompromised Host
Phylogeny
Population

All Science Journal Classification (ASJC) codes

  • Microbiology (medical)

Cite this

Zhang, Ning ; O'Donnell, Kerry ; Sutton, Deanna A. ; Nalim, F. Ameena ; Summerbell, Richard C. ; Padhye, Arvind A. ; Geiser, David M. / Members of the Fusarium solani species complex that cause infections in both humans and plants are common in the environment. In: Journal of clinical microbiology. 2006 ; Vol. 44, No. 6. pp. 2185-2190.
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Members of the Fusarium solani species complex that cause infections in both humans and plants are common in the environment. / Zhang, Ning; O'Donnell, Kerry; Sutton, Deanna A.; Nalim, F. Ameena; Summerbell, Richard C.; Padhye, Arvind A.; Geiser, David M.

In: Journal of clinical microbiology, Vol. 44, No. 6, 01.06.2006, p. 2185-2190.

Research output: Contribution to journalArticle

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AU - O'Donnell, Kerry

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