Membrane tension feedback on shape and motility of eukaryotic cells

Benjamin Winkler, Igor S. Aranson, Falko Ziebert

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

In the framework of a phase field model of a single cell crawling on a substrate, we investigate how the properties of the cell membrane affect the shape and motility of the cell. Since the membrane influences the cell dynamics on multiple levels and provides a nontrivial feedback, we consider the following fundamental interactions: (i) the reduction of the actin polymerization rate by membrane tension; (ii) area conservation of the cell's two-dimensional cross-section vs. conservation of the circumference (i.e. membrane inextensibility); and (iii) the contribution from the membrane's bending energy to the shape and integrity of the cell. As in experiments, we investigate two pertinent observables - the cell's velocity and its aspect ratio. We find that the most important effect is the feedback of membrane tension on the actin polymerization. Bending rigidity has only minor effects, visible mostly in dynamic reshaping events, as exemplified by collisions of the cell with an obstacle.

Original languageEnglish (US)
Pages (from-to)26-33
Number of pages8
JournalPhysica D: Nonlinear Phenomena
Volume318-319
DOIs
StatePublished - Apr 1 2016

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locomotion
membranes
cells
conservation
polymerization
circumferences
rigidity
integrity
aspect ratio
collisions
cross sections

All Science Journal Classification (ASJC) codes

  • Statistical and Nonlinear Physics
  • Mathematical Physics
  • Condensed Matter Physics
  • Applied Mathematics

Cite this

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abstract = "In the framework of a phase field model of a single cell crawling on a substrate, we investigate how the properties of the cell membrane affect the shape and motility of the cell. Since the membrane influences the cell dynamics on multiple levels and provides a nontrivial feedback, we consider the following fundamental interactions: (i) the reduction of the actin polymerization rate by membrane tension; (ii) area conservation of the cell's two-dimensional cross-section vs. conservation of the circumference (i.e. membrane inextensibility); and (iii) the contribution from the membrane's bending energy to the shape and integrity of the cell. As in experiments, we investigate two pertinent observables - the cell's velocity and its aspect ratio. We find that the most important effect is the feedback of membrane tension on the actin polymerization. Bending rigidity has only minor effects, visible mostly in dynamic reshaping events, as exemplified by collisions of the cell with an obstacle.",
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Membrane tension feedback on shape and motility of eukaryotic cells. / Winkler, Benjamin; Aranson, Igor S.; Ziebert, Falko.

In: Physica D: Nonlinear Phenomena, Vol. 318-319, 01.04.2016, p. 26-33.

Research output: Contribution to journalArticle

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