Abstract
In the framework of a phase field model of a single cell crawling on a substrate, we investigate how the properties of the cell membrane affect the shape and motility of the cell. Since the membrane influences the cell dynamics on multiple levels and provides a nontrivial feedback, we consider the following fundamental interactions: (i) the reduction of the actin polymerization rate by membrane tension; (ii) area conservation of the cell's two-dimensional cross-section vs. conservation of the circumference (i.e. membrane inextensibility); and (iii) the contribution from the membrane's bending energy to the shape and integrity of the cell. As in experiments, we investigate two pertinent observables - the cell's velocity and its aspect ratio. We find that the most important effect is the feedback of membrane tension on the actin polymerization. Bending rigidity has only minor effects, visible mostly in dynamic reshaping events, as exemplified by collisions of the cell with an obstacle.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 26-33 |
| Number of pages | 8 |
| Journal | Physica D: Nonlinear Phenomena |
| Volume | 318-319 |
| DOIs | |
| State | Published - Apr 1 2016 |
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All Science Journal Classification (ASJC) codes
- Statistical and Nonlinear Physics
- Mathematical Physics
- Condensed Matter Physics
- Applied Mathematics
Cite this
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Membrane tension feedback on shape and motility of eukaryotic cells. / Winkler, Benjamin; Aranson, Igor S.; Ziebert, Falko.
In: Physica D: Nonlinear Phenomena, Vol. 318-319, 01.04.2016, p. 26-33.Research output: Contribution to journal › Article
TY - JOUR
T1 - Membrane tension feedback on shape and motility of eukaryotic cells
AU - Winkler, Benjamin
AU - Aranson, Igor S.
AU - Ziebert, Falko
PY - 2016/4/1
Y1 - 2016/4/1
N2 - In the framework of a phase field model of a single cell crawling on a substrate, we investigate how the properties of the cell membrane affect the shape and motility of the cell. Since the membrane influences the cell dynamics on multiple levels and provides a nontrivial feedback, we consider the following fundamental interactions: (i) the reduction of the actin polymerization rate by membrane tension; (ii) area conservation of the cell's two-dimensional cross-section vs. conservation of the circumference (i.e. membrane inextensibility); and (iii) the contribution from the membrane's bending energy to the shape and integrity of the cell. As in experiments, we investigate two pertinent observables - the cell's velocity and its aspect ratio. We find that the most important effect is the feedback of membrane tension on the actin polymerization. Bending rigidity has only minor effects, visible mostly in dynamic reshaping events, as exemplified by collisions of the cell with an obstacle.
AB - In the framework of a phase field model of a single cell crawling on a substrate, we investigate how the properties of the cell membrane affect the shape and motility of the cell. Since the membrane influences the cell dynamics on multiple levels and provides a nontrivial feedback, we consider the following fundamental interactions: (i) the reduction of the actin polymerization rate by membrane tension; (ii) area conservation of the cell's two-dimensional cross-section vs. conservation of the circumference (i.e. membrane inextensibility); and (iii) the contribution from the membrane's bending energy to the shape and integrity of the cell. As in experiments, we investigate two pertinent observables - the cell's velocity and its aspect ratio. We find that the most important effect is the feedback of membrane tension on the actin polymerization. Bending rigidity has only minor effects, visible mostly in dynamic reshaping events, as exemplified by collisions of the cell with an obstacle.
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U2 - 10.1016/j.physd.2015.09.011
DO - 10.1016/j.physd.2015.09.011
M3 - Article
AN - SCOPUS:84958781644
VL - 318-319
SP - 26
EP - 33
JO - Physica D: Nonlinear Phenomena
JF - Physica D: Nonlinear Phenomena
SN - 0167-2789
ER -