Memory consolidation in both trace and delay fear conditioning is disrupted by intra-amygdala infusion of the protein synthesis inhibitor anisomycin.

Janine L. Kwapis, Timothy J. Jarome, Janet C. Schiff, Fred J. Helmstetter

Research output: Contribution to journalArticle

41 Scopus citations


Memory for delay fear conditioning requires the synthesis of new mRNA and protein in the basolateral amygdala. It is currently unknown whether similar molecular processes in the amygdala are required for the formation of trace fear memory, in which a stimulus-free interval is inserted between the conditional stimulus (CS) and unconditional stimulus (UCS). Here, we show that infusion of the protein synthesis inhibitor anisomycin into the basolateral amygdala disrupts consolidation of both trace and delay fear conditioning. This is the first evidence that protein synthesis in the amygdala is necessary for the formation of both trace and delay fear memory.

Original languageEnglish (US)
Pages (from-to)728-732
Number of pages5
JournalLearning & memory (Cold Spring Harbor, N.Y.)
Issue number11
StatePublished - Nov 2011


All Science Journal Classification (ASJC) codes

  • Neuropsychology and Physiological Psychology
  • Cognitive Neuroscience
  • Cellular and Molecular Neuroscience

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