MEMS device for continuous blood cell separation

Siyang Zheng, Yu Chong Tai, Harvey L. Kasdan

Research output: Chapter in Book/Report/Conference proceedingConference contribution

4 Scopus citations

Abstract

New experimental results and theory for a unique MEMS device are presented for continuous, binary separation of erythrocytes (RBC) and leukocytes (WBC) based on particle diameter. Previously, we reported the device can separate 5μm, 8μm and 10μm beads as well as two groups of cells in human blood [1]. In this paper, the critical diameter for separation is successfully predicted with simulation and confirmed with experiment. The separation function (lateral displacement versus particle size) was measured experimentally. Separation of labeled leukocytes confirms the device operation. Combined with previous results, leukocyte separation in single device is demonstrated with 91% efficiency.

Original languageEnglish (US)
Title of host publicationMicro Total Analysis Systems - Proceedings of MicroTAS 2005 Conference
Subtitle of host publication9th International Conference on Miniaturized Systems for Chemistry and Life Sciences
PublisherTransducer Research Foundation
Pages385-387
Number of pages3
Volume1
ISBN (Print)0974361119, 9780974361116
StatePublished - Jan 1 2005
Event9th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2005 - Boston, MA, United States
Duration: Oct 9 2005Oct 13 2005

Other

Other9th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2005
CountryUnited States
CityBoston, MA
Period10/9/0510/13/05

All Science Journal Classification (ASJC) codes

  • Chemical Engineering (miscellaneous)
  • Bioengineering

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