MEMS device integrated with vertically aligned carbon nanotubes for virus capture and detection

Yin Ting Yeh, Nestor Perea-Lopez, Yi Tang, Brian U. McKellar, Ramdane Harouaka, Huaguang Lu, Mauricio Terrones, Si Yang Zheng

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations

Abstract

Point-of-care virus diagnosis is highly desirable in worldwide infectious disease control. Here we report a hand-held device for capturing viruses by applying physical size based exclusion inside a point-of-care device integrated with vertically aligned carbon nanotube (VACNT) nanostructures to achieve label-free and high throughput virus capture. The microfluidic device is constructed from a VACNT channel wall synthesized bottom-up via chemical vapor deposition (CVD). The VACNT has ~117nm average gap size and ~97% porosity. By bonding with a polydimethylsiloxane (PDMS) cover sealing the top, the aqueous sample containing virus particles filter through the VACNT channel wall under negative pressure applied at the outlet end. We have demonstrated that the device is capable of filtering 50µL of PBS containing ~6.3×104 counts of lentivirus particles in 10 minutes with 97% of capture efficiency, quantified by the cell infectious titration technique.

Original languageEnglish (US)
Title of host publication2014 Solid-State Sensors, Actuators and Microsystems Workshop, Hilton Head 2014
EditorsMark G. Allen, Mehran Mehregany
PublisherTransducer Research Foundation
Pages17-20
Number of pages4
ISBN (Electronic)9781940470016
DOIs
StatePublished - 2014
Event2014 Solid-State Sensors, Actuators and Microsystems Workshop, Hilton Head 2014 - Hilton Head Island, United States
Duration: Jun 8 2014Jun 12 2014

Publication series

NameTechnical Digest - Solid-State Sensors, Actuators, and Microsystems Workshop

Conference

Conference2014 Solid-State Sensors, Actuators and Microsystems Workshop, Hilton Head 2014
CountryUnited States
CityHilton Head Island
Period6/8/146/12/14

All Science Journal Classification (ASJC) codes

  • Control and Systems Engineering
  • Electrical and Electronic Engineering
  • Hardware and Architecture

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