Meprin metalloprotease expression and regulation in kidney, intestine, urinary tract infections and cancer

Judith S. Bond, Gail L. Matters, Sanjita Banerjee, Renee E. Dusheck

Research output: Contribution to journalShort surveypeer-review

69 Scopus citations

Abstract

Meprins are unique plasma membrane and secreted metalloproteinases that are highly regulated at the transcriptional and post-translational levels. Meprin α and β subunits are abundantly expressed in kidney and intestinal epithelial cells, are secreted into the urinary tract and intestinal lumen, and are found in leukocytes and cancer cells under certain conditions. Their location and proteolytic activities indicate functions at the interface of the host and the external environment, and in trafficking of macrophages and metastases of cancer cells. These proteases can be detrimental when there is tissue damage or disruption, as in acute renal injury or intestinal inflammation, and there is evidence they are involved in movement of leukocytes and cancer cells to sites of infection or in metastasis, respectively.

Original languageEnglish (US)
Pages (from-to)3317-3322
Number of pages6
JournalFEBS Letters
Volume579
Issue number15
DOIs
StatePublished - Jun 13 2005

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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