Merkel cell carcinoma

Michael S. Lehrer, Diane Hershock, Michael E. Ming

Research output: Contribution to journalReview article

12 Citations (Scopus)

Abstract

Merkel cell carcinoma is a rare cutaneous neoplasm most commonly affecting the head and neck of elderly white patients. Even with treatment, Merkel cell carcinoma has a strong, propensity toward local recurrence, lymphatic spread, and distant metastasis. Because of its rarity and the subsequent lack of well-controlled clinical trials, no single standard of care exists for the treatment of this aggressive tumor. In our institution, primary lesions are excised with wide margins or by Mohs' micrographic surgery. After local removal, the excision site is treated locally with external radiation therapy. Sentinel lymph node mapping and biopsy are performed. Patients with tumor within a sentinel lymph node undergo lymph node dissection and radiation to the lymphatic basin. Adjuvant chemotherapy is offered to high-risk patients with local disease and to patients with metastases. Patients with distant metastases are treated with a combination of salvage chemotherapy and radiation therapy.

Original languageEnglish (US)
Pages (from-to)195-199
Number of pages5
JournalCurrent treatment options in oncology
Volume5
Issue number3
DOIs
StatePublished - Jun 2004

Fingerprint

Merkel Cell Carcinoma
Neoplasm Metastasis
Radiotherapy
Mohs Surgery
Sentinel Lymph Node Biopsy
Salvage Therapy
Controlled Clinical Trials
Skin Neoplasms
Adjuvant Chemotherapy
Standard of Care
Combination Drug Therapy
Lymph Node Excision
Neoplasms
Neck
Head
Radiation
Recurrence
Therapeutics

All Science Journal Classification (ASJC) codes

  • Oncology
  • Pharmacology (medical)

Cite this

Lehrer, Michael S. ; Hershock, Diane ; Ming, Michael E. / Merkel cell carcinoma. In: Current treatment options in oncology. 2004 ; Vol. 5, No. 3. pp. 195-199.
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Merkel cell carcinoma. / Lehrer, Michael S.; Hershock, Diane; Ming, Michael E.

In: Current treatment options in oncology, Vol. 5, No. 3, 06.2004, p. 195-199.

Research output: Contribution to journalReview article

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AU - Ming, Michael E.

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