Abstract
The formation of a bipolar mitotic spindle is an essential process for the equal segregation of duplicated DNA into two daughter cells during mitosis. As a result of deregulated cellular signaling pathways, cancer cells often suffer a loss of genome integrity that might etiologically contribute to carcinogenesis. Merkel cell polyomavirus (MCV) small T (sT) oncoprotein induces centrosome overduplication, aneuploidy, chromosome breakage and the formation of micronuclei by targeting cellular ligases through a sT domain that also inhibits MCV large T oncoprotein turnover. These results provide important insight as to how centrosome number and chromosomal stability can be affected by the E3 ligase targeting capacity of viral oncoproteins such as MCV sT, which may contribute to Merkel cell carcinogenesis.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 6784-6792 |
| Number of pages | 9 |
| Journal | Oncogene |
| Volume | 36 |
| Issue number | 49 |
| DOIs | |
| State | Published - Jan 1 2017 |
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All Science Journal Classification (ASJC) codes
- Molecular Biology
- Genetics
- Cancer Research
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Merkel cell polyomavirus small T antigen induces genome instability by E3 ubiquitin ligase targeting. / Kwun, H. J.; Wendzicki, J. A.; Shuda, Y.; Moore, P. S.; Chang, Y.
In: Oncogene, Vol. 36, No. 49, 01.01.2017, p. 6784-6792.Research output: Contribution to journal › Article
TY - JOUR
T1 - Merkel cell polyomavirus small T antigen induces genome instability by E3 ubiquitin ligase targeting
AU - Kwun, H. J.
AU - Wendzicki, J. A.
AU - Shuda, Y.
AU - Moore, P. S.
AU - Chang, Y.
PY - 2017/1/1
Y1 - 2017/1/1
N2 - The formation of a bipolar mitotic spindle is an essential process for the equal segregation of duplicated DNA into two daughter cells during mitosis. As a result of deregulated cellular signaling pathways, cancer cells often suffer a loss of genome integrity that might etiologically contribute to carcinogenesis. Merkel cell polyomavirus (MCV) small T (sT) oncoprotein induces centrosome overduplication, aneuploidy, chromosome breakage and the formation of micronuclei by targeting cellular ligases through a sT domain that also inhibits MCV large T oncoprotein turnover. These results provide important insight as to how centrosome number and chromosomal stability can be affected by the E3 ligase targeting capacity of viral oncoproteins such as MCV sT, which may contribute to Merkel cell carcinogenesis.
AB - The formation of a bipolar mitotic spindle is an essential process for the equal segregation of duplicated DNA into two daughter cells during mitosis. As a result of deregulated cellular signaling pathways, cancer cells often suffer a loss of genome integrity that might etiologically contribute to carcinogenesis. Merkel cell polyomavirus (MCV) small T (sT) oncoprotein induces centrosome overduplication, aneuploidy, chromosome breakage and the formation of micronuclei by targeting cellular ligases through a sT domain that also inhibits MCV large T oncoprotein turnover. These results provide important insight as to how centrosome number and chromosomal stability can be affected by the E3 ligase targeting capacity of viral oncoproteins such as MCV sT, which may contribute to Merkel cell carcinogenesis.
UR - http://www.scopus.com/inward/record.url?scp=85038401152&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85038401152&partnerID=8YFLogxK
U2 - 10.1038/onc.2017.277
DO - 10.1038/onc.2017.277
M3 - Article
C2 - 28846109
AN - SCOPUS:85038401152
VL - 36
SP - 6784
EP - 6792
JO - Oncogene
JF - Oncogene
SN - 0950-9232
IS - 49
ER -