MET alterations and their impact on the future of non-small cell lung cancer (NSCLC) targeted therapies

Matthew Lee, Prantesh Jain, Feng Wang, Patrick C. Ma, Alain Borczuk, Balazs Halmos

Research output: Contribution to journalArticlepeer-review

Abstract

Introduction: The MET gene and its pathway normally plays a crucial role in cell homeostasis, motility, and apoptosis. However, when the MET gene is altered, there is an imbalance toward cell proliferation and invasion commonly seen in numerous different types of cancers. The heterogeneous group of MET alterations that includes MET amplification, MET exon 14 skipping mutation, and MET fusions has been difficult to diagnose and treat. Currently, treatments are focused on tyrosine kinase inhibitors but now there is emerging data on novel MET-targeted therapies including monoclonal antibodies and antibody-drug conjugates that have emerged. Areas covered: We introduce new emerging data on MET alterations in non-small cell lung cancer (NSCLC) that has contributed to advances in MET targeted therapeutics. We offer our perspective and examine new information on the mechanisms of the MET alterations in this review. Expert opinion: Given the trends currently involving the targeting of MET altered malignancies, there will most likely be a continued rapid expansion of testing, novel tyrosine kinase inhibitors and potent antibody approaches. Combination treatments will be necessary to optimize management of advanced and early disease.

Original languageEnglish (US)
Pages (from-to)249-268
Number of pages20
JournalExpert Opinion on Therapeutic Targets
Volume25
Issue number4
DOIs
StatePublished - 2021

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Pharmacology
  • Drug Discovery
  • Clinical Biochemistry

Fingerprint

Dive into the research topics of 'MET alterations and their impact on the future of non-small cell lung cancer (NSCLC) targeted therapies'. Together they form a unique fingerprint.

Cite this