Metabo-miR: miR-211 Regulates Mitochondrial Energy Metabolism in Vitiligo

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Abstract

The study by Sahoo et al. established miR-211 as a critical regulator of cellular metabolism in vitiligo cells. miR-211, which is expressed from the transient receptor potential melastatin 1 intronic region, regulates oxidative phosphorylation and mitochondrial energy metabolism in vitiligo. Loss of miR-211 in melanocytes was shown to alter expression patterns of newly identified target genes, and those that regulate respiratory functions in melanocytes are among them. This study highlights the importance of miR-211 for the melanocyte biology and development of vitiligo.

Original languageEnglish (US)
Pages (from-to)1828-1830
Number of pages3
JournalJournal of Investigative Dermatology
Volume137
Issue number9
DOIs
StatePublished - Sep 2017

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All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Dermatology
  • Cell Biology

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