Metabolic Disorders of the Brain: Part II

Sangam Kanekar, Joel Verbrugge

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Metabolic disorders of the brain are extensive and to encompass these disorders in two articles is impossible. The aim of this article to provide a brief overview of the non-organelle based metabolic disorders affecting the brain. Due to its complexity, classification of the metabolic disorders of brain is not easy. In this article we have discussed the non-organelle based metabolic disorders under following headings: aminoaciduria, organic academia, nuclear DNA repair defects, a defect in the gene encoding myelin proteins and various miscellaneous defects. Even though the neuroimaging findings overlay and may be non-specific for many of the metabolic disorders, some of the imaging features enable the radiologist to provide the physician with a logical approach by providing a road map and/or limiting the differential diagnosis. Understanding the basic biochemical defects is important to recognize these disorders. The relevant biochemistry and genetic defects are also discussed.

Original languageEnglish (US)
Pages (from-to)615-636
Number of pages22
JournalSeminars in Ultrasound, CT and MRI
Volume32
Issue number6
DOIs
StatePublished - Dec 1 2011

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Metabolic Brain Diseases
Myelin Proteins
Neuroimaging
DNA Repair
Biochemistry
Differential Diagnosis
Physicians
Genes

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging

Cite this

Kanekar, Sangam ; Verbrugge, Joel. / Metabolic Disorders of the Brain : Part II. In: Seminars in Ultrasound, CT and MRI. 2011 ; Vol. 32, No. 6. pp. 615-636.
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Metabolic Disorders of the Brain : Part II. / Kanekar, Sangam; Verbrugge, Joel.

In: Seminars in Ultrasound, CT and MRI, Vol. 32, No. 6, 01.12.2011, p. 615-636.

Research output: Contribution to journalArticle

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