Metabolic model guided strain design of cyanobacteria

John I. Hendry, Anindita Bandyopadhyay, Shyam Srinivasan, Himadri B. Pakrasi, Costas D. Maranas

Research output: Contribution to journalReview article

Abstract

Cyanobacteria are oxygenic photoautotrophs that serve as potential platforms for the production of biochemicals from cheap and renewable raw materials – sunlight, water, and carbon dioxide. Systems level analysis of the metabolic network of these organisms could enable the successful engineering of these organisms for the enhanced production of target chemicals. Metabolic modeling techniques including both stoichiometric and kinetic modeling with a genome-wide coverage enable a global assessment of metabolic capabilities. Recent studies guided by such modeling techniques have engineered strains for the enhanced production of valuable chemicals such as ethanol, n-butanol, 1,3-propanediol, glycerol, limonene, and isoprene from CO2.

Original languageEnglish (US)
Pages (from-to)17-23
Number of pages7
JournalCurrent Opinion in Biotechnology
Volume64
DOIs
StatePublished - Aug 1 2020

Fingerprint

1-Butanol
Sunlight
Cyanobacteria
Metabolic Networks and Pathways
Carbon Dioxide
Glycerol
Ethanol
Genome
Water
Isoprene
Butenes
Carbon dioxide
Raw materials
Genes
Kinetics
limonene
isoprene
1,3-propanediol

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Bioengineering
  • Biomedical Engineering

Cite this

Hendry, John I. ; Bandyopadhyay, Anindita ; Srinivasan, Shyam ; Pakrasi, Himadri B. ; Maranas, Costas D. / Metabolic model guided strain design of cyanobacteria. In: Current Opinion in Biotechnology. 2020 ; Vol. 64. pp. 17-23.
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Metabolic model guided strain design of cyanobacteria. / Hendry, John I.; Bandyopadhyay, Anindita; Srinivasan, Shyam; Pakrasi, Himadri B.; Maranas, Costas D.

In: Current Opinion in Biotechnology, Vol. 64, 01.08.2020, p. 17-23.

Research output: Contribution to journalReview article

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AU - Maranas, Costas D.

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