Metabolic modeling of clostridia: Current developments and applications

Satyakam Dash, Chiam Yu Ng, Costas D. Maranas

Research output: Contribution to journalShort survey

26 Citations (Scopus)

Abstract

Anaerobic Clostridium spp. is an important bioproduction microbial genus that can produce solvents and utilize a broad spectrum of substrates including cellulose and syngas. Genome-scale metabolic (GSM) models are increasingly being put forth for various clostridial strains to explore their respective metabolic capabilities and suitability for various bioconversions. In this study, we have selected representative GSM models for six different clostridia (Clostridium acetobutylicum, C. beijerinckii, C. butyricum, C. cellulolyticum, C. ljungdahlii and C. thermocellum) and performed a detailed model comparison contrasting their metabolic repertoire. We also discuss various applications of these GSM models to guide metabolic engineering interventions as well as assessing cellular physiology.

Original languageEnglish (US)
Article numberfnw004
JournalFEMS Microbiology Letters
Volume363
Issue number4
DOIs
StatePublished - Jan 21 2016

Fingerprint

Clostridium
Genome
Clostridium acetobutylicum
Metabolic Engineering
Cellulose

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Molecular Biology
  • Genetics

Cite this

@article{258d0fae5a644efab2c9ff71f527cfa8,
title = "Metabolic modeling of clostridia: Current developments and applications",
abstract = "Anaerobic Clostridium spp. is an important bioproduction microbial genus that can produce solvents and utilize a broad spectrum of substrates including cellulose and syngas. Genome-scale metabolic (GSM) models are increasingly being put forth for various clostridial strains to explore their respective metabolic capabilities and suitability for various bioconversions. In this study, we have selected representative GSM models for six different clostridia (Clostridium acetobutylicum, C. beijerinckii, C. butyricum, C. cellulolyticum, C. ljungdahlii and C. thermocellum) and performed a detailed model comparison contrasting their metabolic repertoire. We also discuss various applications of these GSM models to guide metabolic engineering interventions as well as assessing cellular physiology.",
author = "Satyakam Dash and Ng, {Chiam Yu} and Maranas, {Costas D.}",
year = "2016",
month = "1",
day = "21",
doi = "10.1093/femsle/fnw004",
language = "English (US)",
volume = "363",
journal = "FEMS Microbiology Letters",
issn = "0378-1097",
publisher = "Wiley-Blackwell",
number = "4",

}

Metabolic modeling of clostridia : Current developments and applications. / Dash, Satyakam; Ng, Chiam Yu; Maranas, Costas D.

In: FEMS Microbiology Letters, Vol. 363, No. 4, fnw004, 21.01.2016.

Research output: Contribution to journalShort survey

TY - JOUR

T1 - Metabolic modeling of clostridia

T2 - Current developments and applications

AU - Dash, Satyakam

AU - Ng, Chiam Yu

AU - Maranas, Costas D.

PY - 2016/1/21

Y1 - 2016/1/21

N2 - Anaerobic Clostridium spp. is an important bioproduction microbial genus that can produce solvents and utilize a broad spectrum of substrates including cellulose and syngas. Genome-scale metabolic (GSM) models are increasingly being put forth for various clostridial strains to explore their respective metabolic capabilities and suitability for various bioconversions. In this study, we have selected representative GSM models for six different clostridia (Clostridium acetobutylicum, C. beijerinckii, C. butyricum, C. cellulolyticum, C. ljungdahlii and C. thermocellum) and performed a detailed model comparison contrasting their metabolic repertoire. We also discuss various applications of these GSM models to guide metabolic engineering interventions as well as assessing cellular physiology.

AB - Anaerobic Clostridium spp. is an important bioproduction microbial genus that can produce solvents and utilize a broad spectrum of substrates including cellulose and syngas. Genome-scale metabolic (GSM) models are increasingly being put forth for various clostridial strains to explore their respective metabolic capabilities and suitability for various bioconversions. In this study, we have selected representative GSM models for six different clostridia (Clostridium acetobutylicum, C. beijerinckii, C. butyricum, C. cellulolyticum, C. ljungdahlii and C. thermocellum) and performed a detailed model comparison contrasting their metabolic repertoire. We also discuss various applications of these GSM models to guide metabolic engineering interventions as well as assessing cellular physiology.

UR - http://www.scopus.com/inward/record.url?scp=84960194045&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84960194045&partnerID=8YFLogxK

U2 - 10.1093/femsle/fnw004

DO - 10.1093/femsle/fnw004

M3 - Short survey

C2 - 26755502

AN - SCOPUS:84960194045

VL - 363

JO - FEMS Microbiology Letters

JF - FEMS Microbiology Letters

SN - 0378-1097

IS - 4

M1 - fnw004

ER -