Metabolic phenotype in the brothers of women with polycystic ovary syndrome

Susan Sam, Andrea D. Coviello, Yeon Ah Sung, Richard Legro, Andrea Dunaif

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

OBJECTIVE - Hyperandrogenemia, insulin resistance, and dyslipidemia demonstrate familial aggregation in the female first-degree relatives of women with polycystic ovary syndrome (PCOS), suggesting that these defects are heritable. Hyperandrogenemia also appears to be the male reproductive phenotype. We performed this study to test the hypothesis that brothers of women with PCOS have metabolic defects similar to those of their proband sisters. RESEARCH DESIGN AND METHODS - This was a prospective case-control study performed at four academic medical centers in the U.S. Fasting blood was obtained from 196 non-Hispanic white brothers of women with PCOS and 169 control men of age, BMI, and ethnicity comparable to those of brothers. A separate analysis was performed by study site to assess potential regional variations in metabolic parameters. RESULTS - Overall, brothers of women with PCOS had significantly higher total (P = 0.001) and LDL cholesterol (P = 0.01) as well as triglyceride levels (P = 0.01) compared with control men, although there were regional variations in these differences. There were significant positive correlations between brothers and their sisters with PCOS for total (p = 0.2, P = 0.009) and LDL cholesterol (p = 0.3, P = 0.001) and triglyceride (p = 0.2, P = 0.05) levels. Brothers also had significantly higher fasting insulin levels and homeostatic index of insulin resistance (P = 0.02 for both comparisons) compared with control men. CONCLUSIONS - Brothers of women with PCOS have dyslipidemia as well as evidence for insulin resistance similar to that of their proband sisters with PCOS. These findings are consistent with the hypothesis that some metabolic abnormalities in PCOS are heritable and are not sex specific.

Original languageEnglish (US)
Pages (from-to)1237-1241
Number of pages5
JournalDiabetes Care
Volume31
Issue number6
DOIs
StatePublished - Jun 1 2008

Fingerprint

Polycystic Ovary Syndrome
Siblings
Phenotype
Insulin Resistance
Dyslipidemias
LDL Cholesterol
Fasting
Triglycerides
Case-Control Studies
Research Design
Insulin

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Advanced and Specialized Nursing

Cite this

Sam, Susan ; Coviello, Andrea D. ; Sung, Yeon Ah ; Legro, Richard ; Dunaif, Andrea. / Metabolic phenotype in the brothers of women with polycystic ovary syndrome. In: Diabetes Care. 2008 ; Vol. 31, No. 6. pp. 1237-1241.
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Metabolic phenotype in the brothers of women with polycystic ovary syndrome. / Sam, Susan; Coviello, Andrea D.; Sung, Yeon Ah; Legro, Richard; Dunaif, Andrea.

In: Diabetes Care, Vol. 31, No. 6, 01.06.2008, p. 1237-1241.

Research output: Contribution to journalArticle

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T1 - Metabolic phenotype in the brothers of women with polycystic ovary syndrome

AU - Sam, Susan

AU - Coviello, Andrea D.

AU - Sung, Yeon Ah

AU - Legro, Richard

AU - Dunaif, Andrea

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N2 - OBJECTIVE - Hyperandrogenemia, insulin resistance, and dyslipidemia demonstrate familial aggregation in the female first-degree relatives of women with polycystic ovary syndrome (PCOS), suggesting that these defects are heritable. Hyperandrogenemia also appears to be the male reproductive phenotype. We performed this study to test the hypothesis that brothers of women with PCOS have metabolic defects similar to those of their proband sisters. RESEARCH DESIGN AND METHODS - This was a prospective case-control study performed at four academic medical centers in the U.S. Fasting blood was obtained from 196 non-Hispanic white brothers of women with PCOS and 169 control men of age, BMI, and ethnicity comparable to those of brothers. A separate analysis was performed by study site to assess potential regional variations in metabolic parameters. RESULTS - Overall, brothers of women with PCOS had significantly higher total (P = 0.001) and LDL cholesterol (P = 0.01) as well as triglyceride levels (P = 0.01) compared with control men, although there were regional variations in these differences. There were significant positive correlations between brothers and their sisters with PCOS for total (p = 0.2, P = 0.009) and LDL cholesterol (p = 0.3, P = 0.001) and triglyceride (p = 0.2, P = 0.05) levels. Brothers also had significantly higher fasting insulin levels and homeostatic index of insulin resistance (P = 0.02 for both comparisons) compared with control men. CONCLUSIONS - Brothers of women with PCOS have dyslipidemia as well as evidence for insulin resistance similar to that of their proband sisters with PCOS. These findings are consistent with the hypothesis that some metabolic abnormalities in PCOS are heritable and are not sex specific.

AB - OBJECTIVE - Hyperandrogenemia, insulin resistance, and dyslipidemia demonstrate familial aggregation in the female first-degree relatives of women with polycystic ovary syndrome (PCOS), suggesting that these defects are heritable. Hyperandrogenemia also appears to be the male reproductive phenotype. We performed this study to test the hypothesis that brothers of women with PCOS have metabolic defects similar to those of their proband sisters. RESEARCH DESIGN AND METHODS - This was a prospective case-control study performed at four academic medical centers in the U.S. Fasting blood was obtained from 196 non-Hispanic white brothers of women with PCOS and 169 control men of age, BMI, and ethnicity comparable to those of brothers. A separate analysis was performed by study site to assess potential regional variations in metabolic parameters. RESULTS - Overall, brothers of women with PCOS had significantly higher total (P = 0.001) and LDL cholesterol (P = 0.01) as well as triglyceride levels (P = 0.01) compared with control men, although there were regional variations in these differences. There were significant positive correlations between brothers and their sisters with PCOS for total (p = 0.2, P = 0.009) and LDL cholesterol (p = 0.3, P = 0.001) and triglyceride (p = 0.2, P = 0.05) levels. Brothers also had significantly higher fasting insulin levels and homeostatic index of insulin resistance (P = 0.02 for both comparisons) compared with control men. CONCLUSIONS - Brothers of women with PCOS have dyslipidemia as well as evidence for insulin resistance similar to that of their proband sisters with PCOS. These findings are consistent with the hypothesis that some metabolic abnormalities in PCOS are heritable and are not sex specific.

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